This project aimed to improve handwashing compliance rate among nursing staff in an intensive care unit, through cleaning hands, providing cleaning care, decreasing nosocomial infection, and improving patients' safety. It was found after observations, that incompliance was a result of several factors such as skin irritation due to frequent handwashing, no time for washing, wearing gloves, washing hands after finishing all works, and lack of knowledge. Thereafter, interventions such as handwashing continuing education were held, sterile alcohol solution was placed at the bedside and hand cream was placed at the sink of nursing station. Scheduling with announced hand washing timing, putting up poster at ward to encourage handwashing, putting tag in usual aseptic tray, and designing and storing the remaining draft in computer were applied. After implementation, the handwashing compliance rate increased from 31% to 80%, and the goal-reached rate was 80%. We are honored to share this project with other professionals in this field.