This article describes the nursing treatment experience by using Watson theory in the care of a two-month-old baby from 8th October to 10th December 2009. The baby suffered from congenital heart disease with atrial septal defect, patent ductus arteriosus, and aortic stenosis. The author based the caring process after taking the infant's history through assessment, observation, listening, and conversion. The infant in the ICU had the following major health problems: decreased cardiac output, and risk for infection. The caregiver had the following problems: risk for impaired parentinfant attachment and caregiver role strain. Watson theory was used as a guideline to assess the body needs, the mental and social aspect of the infant and the mother, thus providing the body comfort, and helping the parents to understand the treatment plan; also encourage participating in the care, establishing a relationship between parents and the infant. These strengthened the adaptation skill and learned the way to take care of a congenital heart disease infant. After returning home, parents could independently look after their baby with confidence. By sharing this nursing experience, I hope to encourage nursing staff not only to care for the baby, but also the needs of family on the body, the mental, the social, and the spiritual levels in order to reach the goal of caring for the whole family.