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題名：缺血預適應與運動之相關研究
書刊名：中華體育季刊
作者：陸康豪／林嘉志 引用關係
作者(外文)：Lu, Kang-hao／Lin, Chia-chih
出版日期：2012
卷期：26:2=101
頁次：頁175-182
主題關鍵詞：缺血再灌流；遠端缺血預適應；運動表現；Ischemic reperfusion；remote ischemic preconditioning；exercise performance
原始連結：連回原系統網址new window
相關次數：
  • 被引用次數被引用次數:期刊(4) 博士論文(0) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:4
  • 共同引用共同引用:7
  • 點閱點閱:140
缺血預適應（ischemic preconditioning, IPC）能啟動心臟的保護機制，減緩長時間缺血再灌流後的心肌損傷程度，相關研究至今仍不停發展，且目前已將IPC套用到人體來減緩缺血性運動誘發之細胞凋亡或促進運動表現。人體於運動前先短暫阻斷上臂或大腿的血流，再使血液回流並重覆3到4回合，可模擬IPC並增加自行車最大輸出功率及游泳速度，但對最大耗氧量等生理指標的影響並不一致。目前關於IPC促進運動表現的詳細機轉仍不明確，推測IPC能活化細胞內某些訊息傳遞路徑，透過血管舒張、血流再分配與強化粒線體功能等作用來增加運動表現。
Ischemic preconditioning (IPC) can trigger the mechanism of myocardial protection against prolonged ischemia/reperfusion injury. The IPC-related researches had been still ongoing to date. Moreover, IPC has been used to blunt the degree of ischemic exercise-induced apoptosis or improve exercise performance in human. Brief episodes of occlusion followed by reperfusion of human upper limbs or thighs for 3 to 4 cycles prior to exercise can mimic the efficacy of IPC, which increases cycling maximal power output and swimming velocity. However, the results of IPC in some physiological parameters such as maximal oxygen consumption are inconsistent. The precise mechanism of IPC improving exercise performance is still unclear now. It was speculated that IPC can activate some cellular signaling pathways to enhance sport performance via vasodilation, blood flow redistribution, and /or improvement in mitochondria function.
期刊論文
1.Murry, C. E.、Jennings, R. B.、Reimer, K. A.(1986)。Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium。Circulation，74(5)，1124-1136。  new window
2.林嘉志、姚承義(20061200)。以激效作用觀點探討運動之抗老化機轉。運動生理暨體能學報，5，61-69。new window  延伸查詢new window
3.Crisafulli, A.、Tangianu, F.、Tocco, F.、Concu, A.、Mameli, O.、Mulliri, G.、Caria, M. A.(2011)。Ischemic preconditioning of the muscle improves maximal exercise performance but not maximal oxygen uptake in humans。Journal of Applied Physiology，111(2)，530-536。  new window
4.de Groot, P. C.、Thijssen, D. H.、Sanchez, M.、Ellenkamp, R.、Hopman, M. T.(2010)。Ischemic preconditioning improves maximal performance in humans。European Journal of Applied Physiology，108(1)，141-146。  new window
5.Clevidence, M. W.、Mowery, R. E.、Kushnick, M. R.(2012)。The effects of ischemic preconditioning on aerobic and anaerobic variables associated with submaximal cycling performance。European Journal of Applied Physiology，112(10)，3649-3654。  new window
6.Jean-St-Michel, E.、Manlhiot, C.、Li, J.、Tropak, M.、Michelsen, M. M.、Schmidt, M. R.、Redington, A. N.(2011)。Remote preconditioning improves maximal performance in highly trained athletes。Medicine and Science in Sports and Exercise，43(7)，1280-1286。  new window
7.Pang, C. Y.、Yang, R. Z.、Zhong, A.、Xu, N.、Boyd, B.、Forrest, C. R.(1995)。Acute ischaemic preconditioning protects against skeletal muscle infarction in the pig。Cardiovascular Research，29(6)，782-788。  new window
8.陸希平、陳家玉、蔡宗博、曹昌堯、郭炳宏、郭宗甫(2008)。器官前處置：定義、臨床應用及生物學機轉。臺灣醫學，12(1)，123-128。  延伸查詢new window
9.Cohen, M. V.、Liu, G. S.、Downey. J. M.(1991)。Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits。Circulation，84(1)，341-349。  new window
10.Ambros, J. T.、Herrero-Fresneda, I.、Borau, O. G.、Boira, J. M.(2007)。Ischemic preconditioning in solid organ transplantation: From experimental to clinics。Transplant International \doi\10.1111/j.1432-2277.2006.00418.x，10，219-229。  new window
11.Balakumar, P.、Rohilla, A.、Singh, M.(2008)。Preconditioning and postconditioning to limit ischemia- reperfusion- induced myocardial injury: What could be the next footstep?。Pharmacological Research \doi\10.1016/j.phrs.2008.05.006，57(6)，403-412。  new window
12.Downey, J. M.、Davis, A. M.、Cohen, M. V.(2007)。Signaling pathways in ischemic preconditioning。Heart Failure Reviews \doi\10.1007/s10741-007-9025-2，12(3/4)，181-188。  new window
13.Grisafulli, A.(2006)。Exercise and ischemic preconditioning。Current Cardiology Reviews，2(3)，153-162。  new window
14.Eisen, A.、Fisman, E. Z.、Rubenfire, M.、Freimark, D.、McKechnie, R.、Tenenbaum, A.、Adler, Y.(2004)。Ischemic preconditioning: Nearly two decades of research。A comprehensive review. Atherosclerosis \doi\10.1016/S0021-9150(03)00238-7，172(2)，201-210。  new window
15.Foster, G. P.、Westerdahl, D. E.、Foster, L. A.、Hsu, J. V.、Anholm, J. D.(2011)。Ischemic preconditioning of the lower extremity attenuates the normal hypoxic increase in pulmonary artery systolic pressure。Respiratory Physiology & Neurobiology，179(2/3)，248-253。  new window
16.Kharbanda, R. K.、Nielsen, T. T.、Redington, A. N.(2009)。Translation of remote ischaemic preconditioning into clinical practice。Lancet \doi\10.1016/S0140-6736(09)61421-5，374(9100)，1557-1565。  new window
17.Riksen, N. P.、Zhou, Z.、Oyen, W.、Jaspers, R.、Ramakers, B. P.、Brouwer, R. M.、Rongen, G. A.(2006)。Caffeine prevents protection in two human models of ischemic preconditioning。Journal of the American College of Cardiology \doi\10.1016/j.jacc.2006.04.083，48(4)，700-707。  new window
18.Gurke, L.、Marx, A.、Sutter, P. M.、Frentzel, A.、Salm, T.、Harder, F.、Heberer, M.(1996)。Ischemic preconditioning improves post- ischemic skeletal muscle function。American Surgeon，52(5)，391-394。  new window
19.Keller, D. M.、Ogoh, S.、Greene, S.、Olivencia-Yurvati, A.、Raven, P. B.(2004)。Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle。Journal of Physiology \doi\10.1113/jphysiol.2004.071993，561(1)，273-282。  new window
20.Rongen, G. A.、Oyen, W. J.、Ramakers, B. P.、Riksen, N. P.、Boerman, O. C.、Steinmetz, N.、Smits, P.。Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans。Circulation \doi\10.1161/01.CIR.00001516.12.02223.F2，111(2)，173-178。  new window
21.Reimer, K. A.、Lowe, J. E.、Rasmussen, M. M.、Jennings, R. B.(1977)。The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs。Circulation，56(5)，786-794。  new window
22.Muller, B. A.、Dhalla, N. S.(2010)。Mechanisms of the beneficial actions of ischemic preconditioning on subcellular remodeling in ischemic-reperfused heart。Current Cardiology Reviews \doi\10.2174/157340310793566118，6(4)，255-264。  new window
23.Pasupathy, S.、Homer-Vanniasinkam, S.(2005)。Ischaemic preconditioning protects against ischaemia/reperfusion injury: Emerging concepts。European Journal of Vascular and Endovascular Surgery \doi\10.1016/j.ejvs.2004.11.005，29(2)，106-115。  new window
24.Powers, S. K.、Murlasits, Z.、Wu, M.、Kavazis, A. N.(2007)。Ischemia- reperfusion- induced cardiac injury: A brief review。Medicine & Science in Sports & Exercise \doi\10.1249/mss.0b013e3180d099c1，39(9)，1529-1536。  new window
25.Przyklenk, K.、Bauer, B.、Ovize, M.、Kloner, R. A.、Whittaker, P.(1993)。Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion。Circulation，87(3)，893-899。  new window
26.Przyklenk, K.、Whittaker, P.(2011)。Remote ischemic preconditioning: Current knowledge, unresolved questions, and future priorities。Journal of Cardiovascular Pharmacology and Therapeutics \doi\10.1177/1074248411409040，16(3/4)，255-259。  new window
27.Saito, T.、Komiyama, T.、Aramoto, H.、Miyata, T.、Shigematsu, H.(2004)。Ischemic preconditioning improves oxygenation of exercising muscle in vivo。Journal of Surgical Research \doi\10.1016/j.jss.2003.12.021，120(1)，111-118。  new window
28.Shiki, K.、Hearse, D. J.(1987)。Preconditioning of ischemic myocardium: Reperfusion-induced arrhythmias。American Journal of Physiology，253(6)，H1470-H1476。  new window
29.Tapuria, N.、Kumar, Y.、Habib, M. M.、Abu Amara, M.、Seifalian, A. M.、Davidson, B. R.(2008)。Remote ischemic preconditioning: A novel protective method from ischemia reperfusion injury--a review。Journal of Surgical Research \doi\10.1016/j.jss.2007.12.747，150(2)，304-330。  new window
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