Object: Organ donation is the donation of biological an organ of the human body, from a living or dead person to a living recipient in need of a transplantation. Transplantable organs are removed in a surgical procedure following a determination, based on the donor's medical and social history, of which are suitable for transplantation. However, organ donation is not only getting the organ from the body but also a process to accompany family to deal with the loss and the bereavement. Hospice care is end-of-life care provided by health professionals and volunteers, that it gives medical, psychological and spiritual support and also provides services to support a patient's family. Care on quality of life and the concept of terminal care very importantly, the cumulative value of the concept of hospice work can be used to provide the reference of many severe and terminal care. We recommend the value and work model from hospice care experience to end-of -life care will be a great benefit to organ donation. Case presentation: In order to understand in the case of terminally ill cancer patients in hospice environment agreed to organ donation, we collect underwent hospice cases. We collected executive organ donation of terminal cancer patients in the period from January 2009 to December 2011, and performed the implementation of the assessment of patients with terminal cancer donation rates and analyze the relevant factors. Discussion: A retrospective analysis showed three cancer patients of terminal stage under the mode of hospice care performed corneal organ donation during this period. The donation decision for them and their families are showing different life significance. Conclusions: Our study suggested that the advocating for organ donation in hospice and the bereavement of end-of-life care will both do well.