In the global era, the homogenous techniques and the boundless marketplaces make firms place more weight on the integrated product strategy and design for their innovative product characteristics, in an attempt to strengthen their competitive advantages. There have been abundant practical discussions on strategy in the business settings; however, this article aims to explore and clarify the corresponding implications and the interaction effects between product strategy and design. Methodologically, this research is based on the author's personal observations of design practices in the business settings, and is supplemented with the related literature for further explication and compilation. The body text of this research applies the issues of creative procedures, product strategy and business cases for further examining the interaction effect and the corresponding relationship of strategy and design and their impacts on leadership horizon, organizational sense, working procedure and design orientation. This research concludes by briefing some viewpoints as follows: explicating the interaction effect of product strategy, strategic design and design strategy; highlighting the integrated and interactive key factors; and proposing the required reasons for self-building the logistic system. Finally, the author expects that those viewpoints addressed in this research can benefit firms and practitioners.