Purpose: To investigate factors that affect antihypertensive medicine adherence for patients with hypertension, diabetes mellitus and hyperlipidemia (TW3H). Methods: This retrospective observational study design was implemented by using administrative claims data from the Kaohsiung municipal Feng Shan Hospital (index date between January 2008 and December 2008).The study subjects were patients initially diagnosed as TW3H, then used related hypertensive drugs within index date. The primary diagnosis was defined as not having had TW3H diagnostic code within 12 months prior to index date. Medication adherence was assessed by medication possession ratio (MPR), which calculated by days of utilization of anti-hypertensive drugs, is defined as total days of a drug dispensed to a patient divided by the treatment period (day). Then the treatment period is defined as the initial day of use of anti-hypertensive drugs after the date of first diagnoses of TW3H to the end, 365 days after that day. Results: Statistical analysis results demonstrate that patients' adherence rate improves as the mean daily numbers of antihypertensive pills reach ≧2. In multiple logistic regression analysis, compliance improves in those whose prescription days last between 31 and 60 days. Conclusion: In this study, adjust to a longer prescription day and use a combination of two or more antihypertensive agents may be helpful for increasing patient medication compliance.