本研究主要目的為透過緩和療護之癌末兒童疼痛照護的系統性文獻回顧，同時以專家焦點團體及醫護人員問卷調查建立臨床指引，以提供本土癌末兒童疼痛照顧的依據。研究於2011年1月1日至12月31日間在某醫學中心兒童病房進行。第1階段研究方法採系統性文獻回顧法，查詢1963年至2010年的系統性文獻回顧及臨床指引進行評析，研究工具使用JBI系統文獻評讀表及AGREE中文臨床指引評析表，每篇文獻由2位評讀者獨立萃取；第2階段使用專家焦點團體法，邀請全國兒癌緩和療護專家共19位，進行2次訪談，並將訪談內容轉譯成逐字稿後進行精萃；第3階段採問卷調查法，調查臨床人員對指引的同意程度。研究結果共評讀系統性文獻回顧23篇，經評析後萃取符合高品質實證等級Level I之文獻7篇，Level II共13篇；Grade A共2篇，Grade B 1篇，萃取成64項建議。第2階段專家焦點團體訪談結果共精萃出24項建議，刪除與第1階段建議重複者，並逐項對照後整合成60項。第3階段問卷調查共回收154份，以百分比分析，並以JBI（2007）指引建議等級作為本指引建議的依據；問卷結果同意度<80%1項，刪除後，建立正式指引59項。本研究因實證資料Level II文獻較多，建議未來宜以此指引為基礎，發展較高等級的研究，以提昇癌末兒童安寧緩和療護照護品質。

The purpose of this study is to utilize evidence-based knowledge on palliative care of children with cancer pain. Three phases of study designs were used to develop the clinical guidelines. In phase I, a comprehensive systematic review was conducted. In phase II, an expert focus group was formed to examine the validity of guideline and to collect their opinions. In phase III, a qualitative questionnaires survey was conducted to evaluate the feasibility of the guideline. Studies were performed from 01/01/2011 to 31/12/2011 in the medical center. During the system reviews, 13 databases were searched and focus group studies were followed. We invited 19 professionals who were specialists on the palliative care of children with cancer pain as consultants. The questionnaires were based on system reviews results and focus group studies. Sample size was about 154. Data statistics were analyzed as percentages. The result was to establish clinical guidelines for the palliative care of pediatric patients suffering from cancer pain. The number of Grade A is 49 questions, the agree number of Grade B is 10 questions, there is one question of agrees <80% was deleted. Formal guidelines were established in which 59 cancer pain management guidelines as clinical references.