心室中膈缺損（ventricular septal defects）是常見的心臟異常，占所有先天性心臟疾病的50%，本研究目的是為了瞭解心室中膈缺損青少年的心肺功能及運動能力與一般青少年之間的差異，本研究針對45名心室中膈缺損青少年及44名一般青少年進行心肺功能及運動能力測試。測試結果顯示：在心肺功能部分，心室中膈缺損青少年的用力肺活量與第一秒用力吐氣容積和對照組比較皆無顯著差異，且第一秒用力吐氣容積與用力肺活量的比值及最大自主通氣量方面和對照組也無明顯差異。此外，研究組在運動時的最大心跳數與對照組相比較小，但兩組在最大攝氧量及最大收縮壓部分並無顯著差異。本研究結論：本研究的數據顯示，心室中膈缺損青少年的心肺功能及運動能力與一般青少年比較並無較差的狀況，雖然運動時心臟變速能力不足導致最大心跳比一般青少年差。我們建議未來應多鼓勵心室中膈缺損青少年接受適當的運動訓練，並且可參與體育競賽活動以提升生活品質。

Ventricular septal defect (VSD) is the most common defect (50%) among children diagnosed with pediatric congenital heart disease. This study aimed to evaluate the differences of cardiopulmonary function and exercise capacity between normal adolescents and adolescents with VSDs. A cardiopulmonary exercise stress test was performed for the experimental subjects (n = 45) and control subjects (n = 44). The results of the pulmonary function test showed no variation on forced vital capacity (FVC) or forced expiratory volume in one second (FEV1). Neither statistical differences in maximum voluntary ventilation (MVV) nor FEV1/FVC were noticed. In contrast, healthy participants showed significantly higher maximum heart rate compared to adolescents with VSDs, but no significant differences were found in maximal METs and maximal systolic blood pressure. In conclusion, adolescents with VSDs have a normal cardiopulmonary function and exercise capacity, despite a mild chronotropic limitation. We recommend adolescents with VSDs should be encouraged as receive appropriate exercise training, and can participate in sports competitions in order to enhance the quality of life in the future.