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題名:增進耐力運動表現之相關基因與蛋白質
書刊名:大專體育
作者:曾怡鈞許美智 引用關係
作者(外文):Tseng, Yi-chunHsu, Mei-chich
出版日期:2013
卷期:125
頁次:頁56-64
主題關鍵詞:基因促進基因禁藥基因選才Genetic enhancementGene dopingGene selection
原始連結:連回原系統網址new window
相關次數:
  • 被引用次數被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:1
  • 共同引用共同引用:2
  • 點閱點閱:34
本文主要是探討有潛力運用於增強耐力運動表現相關的基因/蛋白質,包括紅血球生成素、血管內皮生長因子、缺氧誘導因子、血管收縮素轉換酶、過氧化小體增生活化受體γ共同活化子-1α、過氧化物酶體增殖物活化受體和磷酸烯醇式丙酮酸羧激酶之生理作用及其對耐力運動表現之影響。這些基因將可以運用於運動員的基因選才,搭配適合的營養攝取及運動訓練方式,更能將基因的優勢發揮得淋漓盡致。然而基因治療技術之進展亦可能使這些基因被用來取代傳統運動禁藥,進而發展成基因禁藥。
The purpose of this review article is to outline the effects of several functional genes/proteins including erythropoietin, vascular endothelial growth factor, hypoxia-induced factor, angiotensin-converting enzyme, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, peroxisome proliferator-activated receptor delta, and phosphoenolpyruvate carboxykinase on endurance performance. These genes, if used properly, can help identify future elite athletes. However, they can also be abused as a way of gene doping.
期刊論文
1.Narkar, Vihang A.、Downes, Michael、Yu, Ruth T.、Embler, Emi、Wang, Yong-Xu、Banayo, Ester(2008)。AMPK and PPARdelta agonists are exercise mimetics。Cell,134(3),405-415。  new window
2.王杰龍、段子才(2009)。體育運動中的基因興奮劑。阜陽師範學院學報,26(2),52-55。  延伸查詢new window
3.吳忠芳(20051200)。耐力運動表現與血管緊縮素轉化酶。中華體育季刊,19(4)=75,10-16。new window  延伸查詢new window
4.李乾瑋、許美智、蘇柏誠(20051200)。運動訓練與骨骼肌微血管之再生性表現。國立體育學院論叢,16(3),251-258。new window  延伸查詢new window
5.鍾佳蓉、張簡國平(20061200)。運動禁藥--基因重組紅血球生成素。國民體育季刊,35(4)=151,64-67+103。  延伸查詢new window
6.Akhmetov, I. I.、Astranenkova, I. V.、Rogozkin, V. A.(2007)。Association of PPARD gene polymorphism with human physical performance。Molecular Biology (Mosk),41(5),852-857。  new window
7.Ameln, H.、Gustafsson, T.、Sundberg, C. J.、Okamoto, K.、Jansson, E.、Poellinger, L.(2005)。Physiological activation of hypoxia inducible factor-1 in human skeletal muscle。The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology,19(8),1009-1011。  new window
8.Arany, Z.、Foo, S. Y.、Ma, Y.、Ruas, J. L.、Bommi-Reddy, A.、Girnun, G.(2008)。HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha。Nature,451(7181),1008-1012。  new window
9.Basavarajaiah, S.、Wilson, M.、Whyte, G.、Shah, A.、McKenna, W.、Sharma, S.(2008)。Prevalence of hypertrophic cardiomyopathy in highly trained athletes: Relevance to pre-participation screening。Journal of the American College of Cardiology,51(10),1033-1039。  new window
10.Brunmair, B.、Staniek, K.、Dorig, J.、Szocs, Z.、Stadlbauer, K.、Marian, V.(2006)。Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids。Diabetologia,49(11),2713-2722。  new window
11.Chinsomboon, J.、Ruas, J.、Gupta, R. K.、Thom, R.、Shoag, J.、Rowe, G. C.(2009)。The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle。Proceedings of the National Academy of Sciences of the United States of America,106(50),21406。  new window
12.de la Chapelle, A.、Traskelin, A. L.、Juvonen, E.(1993)。Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis。Proceedings of the National Academy of Sciences of the United States of America,90(10),4495-4499。  new window
13.Dolgin, E.(2012)。Gene therapies advance, but some see manufacturing challenges。Nature Medicine,18(12),1718-1719。  new window
14.Folland, J.、Leach, B.、Little, T.、Hawker, K.、Myerson, S.、Montgomery, H.(2000)。Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload。Experimental Physiology,85(5),575-579。  new window
15.Gao, G.、Lebherz, C.、Weiner, D. J.、Grant, R.、Calcedo, R.、McCullough, B.(2004)。Erythropoietin gene therapy leads to autoimmune anemia in macaques。Blood,103(9),3300-3302。  new window
16.Hanson, R. W.、Hakimi, P.(2008)。Born to run: The story of the PEPCK-Cmus mouse。Biochimie,90(6),838-842。  new window
17.Lin, Y. D.、Luo, C. Y.、Hu, Y. N.、Yeh, M. L.、Hsueh, Y. C.、Chang, M. Y.(2012)。Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair。Science Translational Medicine,4(146),146-109。  new window
18.Lippi, G.、Guidi, G. C.(2004)。Gene manipulation and improvement of athletic performances: New strategies in blood doping。British Journal of Sports Medicine,38(5),641-641。  new window
19.Neufeld, G.、Cohen, T.、Gengrinovitch, S.、Poltorak, Z.(1999)。Vascular endothelial growth factor (VEGF) and its receptors。Official Publication of the Federation of American Societies for Experimental Biology,13(1),9-22。  new window
20.O’Hagan, K. A.、Cocchiglia, S.、Zhdanov, A. V.、Tambuwala, M. M.、Cummins, E. P.、Monfared, M.(2009)。PGC-1alpha is coupled to HIF- 1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells。Proceedings of the National Academy of Sciences of the United States of America,106(7),2188-2193。  new window
21.Pascual, J. A.、Belalcazar, V.、de Bolos, C.、Gutierrez, R.、Llop, E.、Segura, J.(2004)。Recombinant erythropoietin and analogues: A challenge for doping control。Therapeutic Drug Monitoring,26(2),175-179。  new window
22.Pilegaard, H.、Saltin, B.、Neufer, P. D.(2003)。Exercise induces transient transcriptional activation of the PGC-1 alpha gene in human skeletal muscle。The Journal of Physiology,546(3),851-858。  new window
23.Puigserver, P.(2005)。Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha。International Journal of Obesity (London,29(1),5-9。  new window
24.Puthucheary, Z.、Skipworth, J. R.、Rawal, J.、Loosemore, M.、Van Someren, K.、Montgomery, H. E.(2011)。The ACE gene and human performance: 12 years on。Sports Medicine,41(6),433-448。  new window
25.Svensson, E. C.、Black, H. B.、Dugger, D. L.、Tripathy, S. K.、Goldwasser, E.、Hao, Z.(1997)。Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector。Human Gene Therapy,8(15),1797-1806。  new window
26.Thompson, P. D.、Tsongalis, G. J.、Ordovas, J. M.、Seip, R. L.、Bilbie, C.、Miles, M.(2006)。Angiotensin-converting enzyme genotype and adherence to aerobic exercise training。Preventive Cardiology,9(1),21-24。  new window
27.Wang, Y. X.、Zhang, C. L.、Yu, R. T.、Cho, H. K.、Nelson, M. C.、Bayuga-Ocampo, C. R.(2004)。Regulation of muscle fiber type and running endurance by PPARdelta。PLOS Biology,2(10),294。  new window
28.Widenfalk, J.、Lipson, A.、Jubran, M.、Hofstetter, C.、Ebendal, T.、Cao, Y.(2003)。Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury。Neuroscience,120(4),951-960。  new window
29.Myerson, S. G.、Montgomery, H. E.、Whittingham, M.、Jubb, M.、World, M. J.、Humphries, S. E.、Pennell, D. J.(2001)。Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: A randomized controlled trial with losartan。Circulation,103(2),226-230。  new window
30.Zhang, B.、Tanaka, H.、Shono, N.、Miura, S.、Kiyonaga, A.、Shindo, M.(2003)。The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle。Clinical Genetics,63(2),139-144。  new window
其他
1.World Anti-Doping Agency(2012)。The 2013 prohibited list,http://www. wada-ama.org/Documents/World_Anti-Doping_ Program/WADP-Prohibited-list/2013/WADA-Prohibited-List-2013-EN.pdf, 20130101。  new window
 
 
 
 
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