Oral hygiene is crucial for patients with ventilators. Clinically, the oral bite was designed to prevent patient biting their endotracheal tube and leading to airway block. Inappropriate placement of foreign objects (e.g oral bite block) in the patient's oral cavity may cause oropharyngeal dysfunction and increase the risk of developing ventilator used related pneumonia. Moreover, misplacement of an oral bite block may not only result in oral mucosal damage and tissue necrosis, but also increase difficulty for nurses to perform oral care for those patients. This study aimed to design an innovative oral bite block for appropriate use. Three types of oral bite blocks were compared in their size, diameters, convenience, and side effects. As a result, the texture of the three oral bite blocks are either very hard, easily causing oral bleeding and ulceration, or spit-out from some patients. Large size oral bite block is also undesirable. The innovative device is created based on the goal of providing better comfort, decreasing possibility of oral bleeding and ulceration, and shortening time of care. Further clinical trial and the approval from the Department of Health will be performed, so more patients could be benefited.