目的：探討咖啡因對中高強度間歇運動後超額攝氧量（excess post exercise oxygen consumption, EPOC）的影響。方法：8位健康男性受試者（年齡：24.4 ± 0.3歲、身高：174.7 ± 2.4公分；體重：70.8 ± 2.8公斤；VO_2peak：38.6 ± 1.7 mg／kg／min）參與兩次平衡交叉，雙盲且間隔至少一週的實驗處理，一次攝取250毫克的咖啡因膠囊，一次則為安慰劑，兩次增補後統一安靜休息90分鐘，隨即進行中高強度運動，運動方式為先以60%VO_2peak的強度進行腳踏車運動20分鐘後，再進行3組80% VO_2peak運動1分鐘，休息1分鐘的間歇性腳踏車運動。採集受試者攝取咖啡因或安慰劑後第0、25、55、85分鐘之安靜心跳率（heart rate, HR）、呼吸交換率（respiratory exchange ratio, RER）及攝氧量（oxygen uptake, VO_2）。實驗過程中也採集受試者增補前（pre-90）、運動前立即（pre-exe）、運動後恢復期的第4分鐘、240分鐘及480分鐘（post-4、post-240、post-480）之前臂靜脈血液，以及運動後60分鐘之攝氧量。統計方法以相依樣本t考驗檢定總EPOC、快速期EPOC及慢速期EPOC；以重複量數雙因子（treatment × time）變異數分析考驗HR、RER、VO_2及血乳酸濃度之交互作用及差異顯著情形。結果：安靜攝氧量部分，時間與組別交互作用達顯著（F = 7.68, p = .028），咖啡因處理在第25分鐘（5.50 ± 0.36 ml／kg／min, p = .004）、第55分鐘（5.17 ± 0.21 ml／kg／min, p = .032）及第85分鐘（5.36 ± 0.23 ml／kg／min, p = .010）之攝氧量，皆顯著高於第0分鐘（4.35 ± 0.19 ml／kg／min）。EPOC部分，僅咖啡因處理（750.86 ± 91.39 ml）之EPOC快速期顯著高於安慰劑處理（600.27 ± 72.19 ml）（p = .043）。結論：攝取250 mg咖啡因可顯著增加安靜時代謝速率，及中高強度間歇運動後之能量消耗，若日後欲進行中高強度間歇運動，且欲增加能量消耗時，建議可於運動前搭配攝取咖啡因。

Purpose: To investigate the effect of caffeine on excess post exercise oxygen consumption (EPOC) after moderate-high intensity exercise. Method: Eight healthy males (age: 24.4 ± 0.3 yr, height: 174.8 ± 2.4 cm, weight: 70.8 ± 2.8, VO_2peak: 38.6 ± 1.7 ml/kg/min) attended two randomized, cross-over, double-blind trials at least one week apart, one with 250 mg caffeine (Caf) and one with placebo (0 mg caffeine; Pla), and after 90 min rest then completed each exercise session (ES) on cycle ergometer. ES consisting of 20 min of cycling at 60% VO_(2peak) follow by 3 sets of 1-min cycling at 80% VO_(2peak) with a 1-min rest between sets. During each ES, resting VO_2 and 60-min post-exercise VO_2 were measured. Blood sample were drawn at 90 min before exercise, pre-exercise, and 30 min, 240 min, 480 min after exercise. Plasma was analyzed for lactate. VO_2 was measured for the 60 min after the exercise. Data from total EPOC, fast phase EPOC, and slow phase EPOC were analyzed by paired t-tests and p ＜ .05 was considered statistically significant. HR, RER, VO_2 and lactate were compared initially through two-way (treatment × time) ANOVA with repeated measures. Result: No significant difference in HR and RER. However, the interaction effect of treatment and time on VO_2 was statistically significant (F = 7.68, p = .028). VO_2 was significantly increased at 25 (5.50 ± 0.36 ml/kg/min), 55 (5.17 ± 0.21 ml/kg/min) and 85 min (5.36 ± 0.23 ml/kg/min) than before (4.35 ± 0.19 ml/kg/min) (p = .004, p = .032, p = .010) supplementation in caffeine trail. Fast phase of EPOC in caffeine trail was significantly higher than placebo (750.86 ± 91.39 ml vs. 600.27 ± 72.19 ml, p = .043). Conclusion: Ingestion of caffeine 250 mg could increase the ratio of rest metabolism, as well as after middle-high intensity interval exercise.