This article discussed the nursing experience of a patient with osteonecrosis of femoral head undergoing a total hip replacement surgery. The care was from the 19th to the 26th of December 2011. We collected the data via observation chart reviews, preoperative and postoperative consultation. Health problems assessed based on Gordon’s 11 Functional Health Patterns Assessment included (1) anxiety/ related to facing the procedure and the uncertain outcome; (2) the potential hazard of the risky procedure/ related to the surgery, anesthesia, and environmental factors; (3) acute pain/ related to the surgical tissue injury; and (4) lack of knowledge/ related to the postoperative self care. During the course of nursing, we assessed the needs of the patient, timely offered psychological support, drew up nursing care plan according to the patient’s conditions, and provide information about total hip replacement surgery and education for artificial hip joint dislocation prevention; effectively lowering patient’s anxiety about the surgery. There was no unexpected peri-operative event, alleviating postoperative pain. Most importantly, the patient was motivated to improve self-care ability and be able to back to his daily life. We hope that the experience can serve as a reference for improving quality of care for patients undergoing total hip replacement surgery.