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題名：眼科民間保健藥用植物毛山葡萄之成分研究
書刊名：健康管理學刊
作者：謝明學
作者(外文)：Shieh, Ming-shueh
出版日期：2013
卷期：11:2
頁次：頁148-155
主題關鍵詞：毛山葡萄；眼科民間藥；三萜類；Ampelopsis brevipedunculata var.；ciliate (Nakai) Lu.；Ophthalmic folk medicines；Triterpenoid；Lupeol；Lupenone；Squalene；Cycloarteno
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由台灣產民間治療眼疾保健植物毛山葡萄Ampelopsis brevipedunculata var. ciliate （Nakai）Lu.分離出四種三萜類化合物（lupeol, lupenone, squalene, cycloartenol）兩種酚類化合物，並用EI-MS，IR，1H-NMR，13C-NMR等光譜分析技術測定成分的化學結構。其中化合物lupeol及squalene，據文獻報 導，它能促進視網膜色素上皮細胞（RPE）的吞噬作用。
Four known triterpenoids (lupeol, lupenone, squalene, cycloartenol) and two phenolic compounds were isolated from Ampelopsis brevipedunculata var. ciliate (Nakai) Lu. of the Ophthalmic Folk Medicines in Taiwan. According to the literature, lupeol and squalene can enhance Retinal Pigment Epithelial (RPE) cell phagocytosis in retina. Structure determination was carried out by spectral techniques such as, EI-MS, IR, 1H-NMR and 13C-NMR.
期刊論文
1.Allsop, I. L.、Cole, A. R. H.、White, D. E.、Willix, R. L. S.(1956)。Infrared Spectra of Natural Products. Part VI. The Characterization of Equatorial and Axial 3-Hydroxyl Groups in Triterpenoids。J. Chem. Soc.，1956，4868-4873。  new window
2.Bryan, J. A.、Campochiaro, P. A.(1986)。A Retinal Pigment Epithelial Cell-Derived Growth Factor(s)。Arch Ophthalmol，104(3)，422-425。  new window
3.Budzikiewicz, D. H.、Wilson, J. M.、Djerassi, C.(1962)。Mass Spectrometry in Structural and Stereochemical Problems Unsaturated Pentacyclic Triterpenoids。Tetrahedron Letters，7，263-270。  new window
4.Chan, C. C.、Hooks, J. J.、Nussenblatt R. B.、Detrick, B.(1986)。Expression of La Antigen on Retinal Pigment Epithelium in Experimental Autoimmune Uveoretinitis。Curr. Eye Res.，5(4)，325-330。  new window
5.Djerassi, C.、Farkast, E.、Liu, L. H.、Thomas, G. H.(1955)。The Cactus Triterpenes Thurberogenin and Stellatogenin。J. Am. Chem. Soc.，77，5330-5534。  new window
6.Ernst, J.(1976)。The Crystal Structure of Squalene。Angew. Chem. Int. Ed.，15，778。  new window
7.Glaser, B. M.、Campochiaro, P. A.、Davis, J. L.、Sato, M.(1985)。Retinal Pigment Epithelial Cells Release an Inhibitor of Neovascularization。Arch Ophthalmol，103，1870-1875。  new window
8.Glaser, B. M.、Campochiaro, P. A.、Davis, J. L.、Jerdan, J. A.(1987)。Retinal Pigment Epithelial Cells Release inhibitors of Neovascularization。Ophthalmology，94，780-784。  new window
9.Kato, T.、Yamane, F.、Morita, Y.(1990)。The Flavonol Glycosides from Ampelosis Brevipedunculata Trautv。Chem. Abstr.，112，195-288。  new window
10.Kato, T.、Yamane, F.、Morita, Y.(1991)。Flavonol Glycosides and Other Constituents from the Leaves of Ampelopsis Brevipedunculata Trautv。Chem. Abstr.，114，588-590。  new window
11.Kinoshita, J. H.、Merola, O. L.(1962)。Osmotic Changes in Experimental Galactose Cataracts。Exp. Eye Research，1，405-410。  new window
12.Nes, W. D.、Schmidt, J. O.(1988)。Isolation of 25(27)-Dehydrolanost-8-enol from Cereus Giganteus and Its Biosynthetic Implications。Phytochemistry，27(6)，1705-1708。  new window
13.Oshima, Y.、Ueno, Y.、Hikion, H.(1990)。Ampelopsins A, B and C, new oligostilbenes of VAR。Tetrahedron，46，5121-5126。  new window
14.Radies, L.、Kajar-Peredy, M.(1975)。Carbon-13 NMR Spectra of Some Polycyclic Triterpenoid。Tetrahedron Letters，48，4287-4290。  new window
15.Shimizu, M.、Horie, S.、Arisawa, M.、Hayashi, T.、Suzuki, S.、Morita, N.、Basualdo, I.(1987)。Chemical and Pharmaceutical Studies on Medicinal Plant in Paraguay. I. Isolation and Indentification of Lens Aldose Reductase Inhibitor from Tapecue Acanthospermum Australe O.K.。Chem. Pharm. Bull.，35(3)，1234-1237。  new window
16.Sholichin, M.、Yamasaki, K.、Kasai, R.、Tanaka, O.(1980)。Carbon-13 Nuclear Magnetic Resonance of Lupan-Type Triterpens, Lupeol, Betulin and Betulinic Acid。Chem. Pharm. Bull.，28(3)，1006-1008。  new window
17.Tanimoto, T.、Fukuda, H.、Sato, H.(1983)。Sorbitol Pathway in Lenses of Normal and Diabetic Rabbits。Chem, Pharm. Bull.，31，204-208。  new window
18.Tomas-Barberan, F. A.、Lopez-Gomez, C.、Villar, A.、Tomas-Lorente, F.(1986)。Inhibition of Lens Aldose Reductase by Labiatae Flavonoids。Planta Medica，52(3)，239-240。  new window
19.Varma, S. D.、Kinoshita, J. H.(1974)。The Absence of Cataracts in Mice with Congenital Hyperglycemia。Exp. Eye Research，19，577-582。  new window
20.Wenkert, E.、Baddeley, G. V.、Burfitt, I. R.、Moreno, L. N.(1978)。Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Naturally-Occurring Substances- LVII Triterpenes Related to Lupane and Hopane。Org. Magn. Reson.，11，337-343。  new window
21.顏焜熒、李文雄、李哲夫(19671200)。Studies on the Pharmacological Effective Components of Local Plants in Taiwan(II) The Antibiotic Activity and Pharmacological Action of Ampelopsis Brevipedunculata Traut, Var. Hancei Li。臺灣藥學雜誌，19(1/2)，15-20。  new window
學位論文
1.劉瓊琳(2009)。漢氏山葡萄莖部化學成分及生物活性之研究(碩士論文)。屏東科技大學。  延伸查詢new window
圖書
1.王竹賢、何聖佑(1988)。從眼睛看全身疾病。台北：藝軒圖書。  延伸查詢new window
2.吳邦新(2009)。從眼睛虹膜看健康。白象文化。  延伸查詢new window
3.許鴻源(1979)。漢方對疑難症之治療--癌腫篇。台北：新醫藥出版社。  延伸查詢new window
4.許鴻源(1972)。台灣地區出產中藥藥材圖鑑。台北：行政院衛生署中醫藥委員會。  延伸查詢new window
5.Lewis, W. H.、Elvin-Lewis, M. P. F.(1977)。Medical Botany (plants affecting man's health。New York：John Wiley & Sons。  new window
6.Li, H. L.、Liu, T. S.、Hung, T. C.、Koyama T.、Devol, C. E.(1976)。Flora of Taiwan。Taipei：Epoch publishing Co. Ltd.。  new window
7.Pouchert, C. J.(1983)。The Aldrich Library of IR spectra。  new window
 
 
 
 
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