The occurrence of muscloskeletal ache may lead to fatigue, inattention, poor quality of sleep, efficiency of work and quality of life. Taiwanese spend approximately over 100 billion dollars on pain management. More than a half of people do not ask for help from physicians, but would like to use plasters or other equipment. Therefore, it is critical to develop a pain-curing equipment with multiple functions. Through the analysis of all types of pain-curing equipment and interview with 100 nurses, technological staffs, and elders, using a self-report questionnaires of neck-shoulder pain, the result indicates that the single functions, expensive, heavy body, and hard to accurately use are the disadvantage of current pain curing equipment. The “four-in-one pain roller” was developed based on the measurement of human anatomy. The roller can be adjusted to the different angles of the human body, so the plaster or ointment can be applied on the area precisely. The roller can be also used for message and scratching.