Background: In this home nursing unit, the storage cabinets were massed up because healthcare materials were either in-correctly positioned or excessive appropriation; however, some deficiencies of healthcare materials required urgent borrowing, resulting in adversely affected work productivity. This project was an attempt to promote the concepts of warehouse manage-ment and inventory costs of medical and healthcare stock for home care nurses, in order to enhance patient safety, to provide high-quality service, and to achieve cost control. Methods: Poor storage devices and unclear labeling for healthcare materials were found using the audit checklist. Evaluation using questionnaire indicated that personnel were lack of knowledge about healthcare materials. The problems of management process included incomplete informatization, unmatched resource usage and material flows. Therefore, this project was designed to develop materials management prac-tices, to establish the system of auditing, education and training, to restructure the space, to change pricing program for simpli-fying the payment approval process. Results: After implementing strategies for these objectives, the knowledge about management of healthcare materials was im-proved from 60% to 96.7%. In addition, abnormal resource us-age (excess stock, partial shortages, and expiration) and mate-rial flows were reduced to 5%, 10%, 0% and the time required for payment approval process was shortened from 277 seconds to 66 seconds. Conclusions: The improvements achieved in the concepts of medical material management, costs, professional managing capabilities, and health care quality might be used as a refer-ence model providing effective management for other relevant medical units.