Background: There are more than 80% patients who stay in Intensive Care Unit (ICU) has to proceed endotracheal intubation treatment due to server respiratory failure. Unplanned removal of endotracheal tube during stay in ICU not only could prolong the treatment period and increased the length of stay in hospital, but also threaten life. Purposes: The purpose of this study is to reduce the rate of unplanned endotracheal tube removal in ICU. Methods: After cause analyzing from the 20 cases who were suffered unplanned endotracheal tube removal in ICU in 2011. The team resources management mode was utilized to build up certain interventions in order to improve this situation, such as leadership, situational monitoring, team supporting and communication. Results: After engaging interventions from January 2012 to May 2013, the rate of unplanned endotracheal tube removal has decreased from 0.27% in 2011 to 0.14% in 2012 by 12 cases. This reached the study goal. Conclusions: This study not only applied the team resources management mode to prevent unplanned endotracheal tube removal which had achieved significant positive result, but also increased patients’ safety. Besides, positive negotiation climate in working place had established through management strategy.