This case study describes the use of therapeutic play to help a preschool child with acute lymphoblastic leukemia to reduce fear of Port-A insertion. Due to the specific fear of Port-A insertion, he appeared behavioral responses like crying loudly and fearful reaction, therefore the mother could not help but clutch him to accept Port-A insertion every time. We took preschooler’s developmental features and favorite cartoon characters into consideration and combined various types of therapeutic play, including “emotional outlet play” and “instructional play”, the theme of the play was chosen as “Legend of Optimus Prime and the Angry Birds”. To be brief, the whole instructions indicated Hero Optimus Prime needed to transport energy from Port-A. On the perspective of atraumatic care, several kinds of real medical supplies and handmade Port-A intravenous drip prop would be used to ease the client at the same time and helped the client adapting. The project comprises four ways to divert attention, including Angry Birds Blow Panpipe (made with plastic straws and it worked as a simple music instrument), Angry Birds Counting Board (count how many angry birds there are on the board and divide them into groups), Space Campanula (pull the rope and bell rings), and Little Bad Egg (young client can hold and squeeze them while injected), hence the client could express emotion and divert attention, with the guidance of the procedure of the Port-A insertion. His mother also learned how to act in the hero stories as a role model to pacify the child that he was a hero to be brave. This therapeutic play focused on the client’s needs and interests to attain the effectiveness of reducing fear, expressing emotion and distraction. If we could uphold the principles of “atraumatic care” and use of therapeutic play appropriately to assist the child to reduce the fear of Port-A insertion, psychological trauma will be minimized, the “child-friendly healthcare” will be implemented.