In the Edo period, the Japanese people lived in a closed state, seldom seeing foreigners. Those who drifted overseas were repatriated in the end, often stopping at Macau and Guangzhou on their way back. After being rescued, these drifters arrived Macau. They headed to Zhejiang via Guangzhou. During their stay in Macau, they were well treated by both the locals and foreigners in Macau. Macau was the intersection of trading between the West and the East and was quite prosperous at that time. Drifters also witnessed prosperity of Guangzhou on the way to Zhejiang. Relevant records can be foundin the Chang Qi Zhi Xu Pian《長崎志續篇》, Tong Hang Yi Lan《通航一覽》, Sa Zhou PiaoKe Jian Wen Lu《薩州漂客見聞錄》, giving testimony to the conditions of the two places at that time. It also reveals that the cultural observation of the two places by the Japanese provides valuable material for studying the history of the relationship between Macau and Japan in the Ming and Qing dynasties.