This report described the nursing experiences of a terminal liver cancer patient who has received physical, psychological, and spiritual care in the hospice. During November 27 to December 23, 2014, I performed the physical, psychosocial, and spiritual assessments through the hospice care techniques, such as physical examination, talking, listening, and observation of the family interaction, based on the holistic nursing assessment. After the assessment, I noticed that the patient had the problems of chronic pain, anticipatory grief, and the spiritual distress, etc. The nursing care plan for pain relieving was applied by medical therapy and complementary therapies. I encourage the patient to express his sorrow, feelings of loss and needs, and also encourage his family members to face the patient's wish of going home. Through the creation of good nurse-patient relationship, therapeutic communication, actively listening, and accompany, the patient's wish was fulfilled. I helped the patient to find the meaning of life through conversation, counseling, and life review gradually, and praised his effort and contribution to his family to identify his self-value. With the assistance of the social worker and the religious worker, the patient understood that death is a natural course. Finally, he could bravely face, accept, and prepare his own death and obtain peace of mind at the end of life. The report provided the nursing experience of biopsychosocial and spiritual care for a patient of hepatocellular carcinoma in terminal stage, which helped me to perform the holistic nursing assessment for terminal cancer patient in the future. Based on this experience, the nurses need to enrich the hospice related professional knowledge and abilities in order to maintain the quality of nursing care and obtain self-spiritual growth.