運動誘發鳶尾素對肥胖合併間歇性低氧引起心肌纖維化的影響_

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題名：	運動誘發鳶尾素對肥胖合併間歇性低氧引起心肌纖維化的影響
書刊名：	大專體育學刊
作者：	陳聰毅／王冠捷
作者(外文)：	Chen, Tsung-i／Wang, Guan-jie
出版日期：	2017
卷期：	19:3
頁次：	頁272-287
主題關鍵詞：	睡眠呼吸中止症；高脂飲食；骨骼肌；Sleep apnea；High fat diet；Skeletal muscle
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:2 點閱:1

本研究目的以動物模式模擬阻塞型睡眠呼吸中止症夜間之間歇性低氧現象，配合高脂飲食誘發肥胖，探討運動誘發鳶尾素對肥胖合併阻塞型睡眠呼吸中止症引起心肌纖維化的影響。將8週齡Sprague-Dawley雄性大鼠隨機先分成控制(control, CON)、間歇性低氧(intermittent hypoxia, IH)、運動(exercise, EXE)及IH配合EXE(IHEXE)組，各組再次分為正常飲食(normal diet, ND)及高脂飲食(high fat diet, HFD)2組，共計8組。運動訓練方式：在動物跑步機上進行12週運動訓練。IH模式：於第11 ~ 12週時，進行14天IH(8小時／天)曝露。動物犧牲後主要分析副睪及腎周邊脂肪量、比目魚肌及腓腸肌重量、心肌纖維化指標、腫瘤壞死因子-α(tumor necrosis factor-α, TNF-α)、介白素-6 (interleukin-6, IL-6)及骨骼肌鳶尾素表現量。研究結果顯示：與ND組比較，HFD導致CON、IH、EXE及IHEXE組之副睪及腎周邊脂肪量均明顯增加。與CON+ND組比較，CON+HFD及IH+ND組心肌纖維化指標、TNF-α 及IL-6表現量均明顯上升。在餵食ND及HFD各組間與IH組比較，EXE及IHEXE組均有較低副睪脂肪及腎周邊脂肪重量、心肌纖維化指標、心肌TNF-α及IL-6表現量與較高比目魚肌與體重比值、腓腸肌與體重比值及骨骼肌鳶尾素表現量。本研究結論為12週運動訓練增加骨骼肌鳶尾素表現量，可能與降低高脂飲食及間歇性低氧引起心肌纖維化的抗纖維化機轉有關。

以文找文

The purpose of this study was to investigate whether irisin plays a key role in exercise-mediated effects on cardiac fibrosis in obese rats with obstructive sleep apnea (OSA). We used high-fat diet to develop obese animal model, which displays the intermittent hypoxia seen in OSA. Eight-week old male Sprague-Dawley rats were randomly assigned into control (CON), intermittent hypoxia (IH), exercise (EXE) and IH-induced in EXE (IHEXE) groups. Each group again divided into two subgroups, namely normal diet (ND) and high-fat diet (HFD) groups. The exercise and hypoxia protocols were explained as follows; exercise protocol: rats were trained on an animal treadmill for 12 weeks. IH exposure: at the week 11 and 12, rats were exposed to IH (8 hours/day) for 14 days. After the last treatment, rats were sacrificed, and the weights of epididymal fat, perirenal fat, soleus and gastrocnemius muscle were recorded. The myocardial levels of fibrosis index, concentrations of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and irisin expression in skeletal muscle were determined. The findings in this study showed that compared to ND, HFD feeding increased the weight of epididymal and perirenal fat in CON, IH, EXE and IHEXE groups. Compared to CON+ND group, rats in CON+HFD and IH+ND group showed significantly higher levels of cardiac fibrosis index, myocardial TNF-α and IL-6 concentrations (p ＜ .05). We found lower weights of epididymal and perirenal fat, lower levels of cardiac fibrosis index, myocardial TNF-α and IL-6 in EXE and IHEXE rats compared to IH rats with ND and HFD. Moreover, higher soleus muscle to body weight ratio, gastrocnemius muscle to body weight ratio and upregulated irisin expression in skeletal muscle were found in EXE and IHEXE groups compared to IH group. In conclusion, 12-week exercise training can provide potent anti-fibrotic effects by attenuating the HFD- and IH-induced cardiac fibrosis in rats that is possibly through enhanced irisin expression in skeletal muscle.

以文找文

期刊論文
1.	Pedersen, B. K.、Fischer, C. P.(2007)。Beneficial health effects of exercise--the role of IL-6 as a myokine。Trends in Pharmacological Sciences，28(4)，152-156。
2.	Prabhakar, N. R.(2001)。Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms。Journal of Applied Physiology，90(5)，1986-1994。
3.	Siu, P. M.、Bryner, R. W.、Martyn, J. K.、Alway, S. E.(2004)。Apoptotic adaptations from exercise training in skeletal and cardiac muscles。The FASEB Journal，18(10)，1150-1152。
4.	Ares-Carrasco, S.、Picatoste, B.、Benito-Martin, A.、Zubiri, I.、Sanz, A. B.、Sanchez-Nino, M. D.、Lorenzo, O.(2009)。Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes。American Journal of Physiology. Heart and Circulatory Physiology，297(6)，H2109-H2119。
5.	Baguet, J. P.、Barone-Rochette, G.、Tamisier, R.、Levy, P.、Pepin, J. L.(2012)。Mechanisms of cardiac dysfunction in obstructive sleep apnea。Nature Reviews Cardiology，9(12)，679-688。
6.	Lin, Yueh-min、Huang, Shu-kuei、Wang, Hsueh Fang、Chen, Li-mien、Tsai, Fuu-jen、Hsu, Hsi-hsien、Kuo, Chia-hua、Wang, Paulus S.、Huang, Chih-yang、Lee, Shin-da(20081000)。Short-Term Versus Long-Term Intermittent Hypobaric Hypoxia on Cardiac Fibrosis and Fas Death Receptor Dependent Apoptotic Pathway in Rat Hearts。中國生理學雜誌，51(5)，308-316。
7.	林瑞興(20060900)。運動訓練介入對左心室構造功能之影響。大專體育學刊，8(3)，149-159。延伸查詢
8.	Al-Daghri, N. M.、Alokail, M. S.、Rahman, S.、Amer, O. E.、Al-Attas, O. S.、Alfawaz, H.、Piya, M. K.(2015)。Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2。European Journal of Clinical Investigation，45(8)，775-781。
9.	Aoi, W.、Naito, Y.、Takagi, T.、Tanimura, Y.、Takanami, Y.、Kawai, Y.、Yoshikawa, T.(2013)。A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise。Gut，62(6)，882-889。
10.	Eschalier, R.、Rossignol, P.、Kearney-Schwartz, A.、Adamopoulos, C.、Karatzidou, K.、Fay, R.、Zannad, F.(2014)。Features of cardiac remodeling, associated with blood pressure and fibrosis biomarkers, are frequent in subjects with abdominal obesity。Hypertension，63(4)，740-746。
11.	Evans, C. A.、Selvadurai, H.、Baur, L. A.、Waters, K. A.(2014)。Effects of obstructive sleep apnea and obesity on exercise function in children。Sleep，37(6)，1103-1110。
12.	Yin, X.、Zhou, S.、Zheng, Y.、Tan, Y.、Kong, M.、Wang, B.、Cai, L.(2014)。Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice。Toxicology and Applied Pharmacology，277(1)，58-66。
13.	Seldin, M. M.、Peterson, J. M.、Byerly, M. S.、Wei, Z.、Wong, G. W.(2012)。Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis。Journal of Biological Chemistry，287(15)，11968-11980。
14.	Stengel, A.、Hofmann, T.、Goebel-Stengel, M.、Elbelt, U.、Kobelt, P.、Klapp, B. F.(2013)。Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--Correlation with body mass index。Peptides，39，125-130。
15.	Mahajan, R. D.、Patra, S. K.(2013)。Irisin, a novel myokine responsible for exercise induced browning of white adipose tissue。Indian Journal of Clinical Biochemistry，28(1)，102-103。
16.	Olea, E.、Agapito, M. T.、Gallego-Martin, T.、Rocher, A.、Gomez-Niño, A.、Obeso, A.、Yubero, S.(2014)。Intermittent hypoxia and diet-induced obesity: Effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure。Journal of Applied Physiology，117(7)，706-719。
17.	Ozeke, O.、Ozer, C.、Gungor, M.、Celenk, M. K.、Dincer, H.、Ilicin, G.(2011)。Chronic intermittent hypoxia caused by obstructive sleep apnea may play an important role in explaining the morbidity-mortality paradox of obesity。Medical Hypotheses，76(1)，61-63。
18.	Chen, L.、Einbinder, E.、Zhang, Q.、Hasday, J.、Balke, C. W.、Scharf, S. M.(2005)。Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats。American Journal of Respiratory and Critical Care Medicine，172(7)，915-920。
19.	Lavie, L.、Kraiczi, H.、Hefetz, A.、Ghandour, H.、Perelman, A.、Hedner, J.、Lavie, P.(2002)。Plasma vascular endothelial growth factor in sleep apnea syndrome: Effects of nasal continuous positive air pressure treatment。American Journal of Respiratory and Critical Care Medicine，165(12)，1624-1628。
20.	黃森芳、陳聰毅(20151200)。運動對肥胖合併阻塞型睡眠呼吸中止症引發心臟功能損傷之影響：肌肉激素的角色。大專體育，135，67-77。延伸查詢
21.	黃森芳、黃國欽、陳聰毅(20151200)。運動對阻塞型睡眠呼吸中止症引發心臟功能損傷之影響：鈉氫離子交換蛋白的角色。中華體育季刊，29(4)=115，301-309。延伸查詢
22.	Aoi, W.、Sakuma, K.(2013)。Skeletal muscle: A novel and intriguing characteristics as a secretory organ。BioDiscovery，7。
23.	Badran, M.、Golbidi, S.、Devlin, A.、Ayas, N.、Laher, I.(2014)。Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity。Sleep Medicine，15(5)，596-602。
24.	Bostrom, P.、Wu, J.、Jedrychowski, M. P.、Korde, A.、Ye, L.、Lo, J. C.、Spiegelman, B. M.(2012)。A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis。Nature，481(7382)，463-468。
25.	Chen, M. Y.-C.、Yang, K.-T.、Shen, Y.-J.、Cheng, C.-F.、Tu, W.-C.、Chen, T.-I.(2015)。Role of sodium-hydrogen exchanger-1 (NHE-1) in the effect of exercise on intermittent hypoxia-induced left ventricular dysfunction。Chinese Journal of Physiology，58(4)，254-262。
26.	Chen, T.-I.、Tu, W.-C.(2016)。Exercise attenuates intermittent hypoxia-induced cardiac fibrosis associated with sodium-hydrogen exchanger-1 in rats。Frontiers in Physiology，7。
27.	Chen, T.-I.、Shen, Y.-J.、Wang, I.-C.、Yang, K.-T.(2011)。Short-term exercise provides left ventricular myocardial protection against intermittent hypoxiainduced apoptosis in rats。European Journal of Applied Physiology，111(8)，1939-1950。
28.	Kuusisto, J.、Kärjä, V.、Sipola, P.、Kholová, I.、Peuhkurinen, K.、Jääskeläinen, P.、Laakso, M.(2012)。Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy。Heart，98(13)，1007-1013。
29.	Koyama, R. G.、Esteves, A. M.、Oliveira e Silva, L.、Lira, F. S.、Bittencourt, L. R. A.、Tufik, S.、de Mello, M. T.(2012)。Prevalence of and risk factors for obstructive sleep apnea syndrome in Brazilian railroad workers。Sleep Medicine，13(8)，1028-1032。
30.	Kania, G.、Blyszczuk, P.、Eriksson, U.(2009)。Mechanisms of cardiac fibrosis in inflammatory heart disease。Trends in Cardiovascular Medicine，19(8)，247-252。
31.	Golbidi, S.、Laher, I.(2014)。Exercise induced adipokine changes and the metabolic syndrome。Journal of Diabetes Research，2014。
32.	Mahajan, R.、Lau, D. H.、Sanders, P.(2014)。Impact of obesity on cardiac metabolism, fibrosis, and function。Trends in Cardiovascular Medicine，25(2)，119-126。
33.	Park, A. M.、Nagase, H.、Vinod Kumar, S.、Suzuki, Y. J.(2007)。Acute intermittent hypoxia activates myocardial cell survival signaling。American Journal of Physiology: Heart and Circulatory Physiology，292(2)，H751-H757。
34.	Raschke, S.、Eckel, J.(2013)。Adipo-myokines: Two sides of the same coin--Mediators of inflammation and mediators of exercise。Mediators of Inflammation，2013。
35.	Sun, Y.、Yi, W.、Yuan, Y.、Lau, W. B.、Yi, D.、Wang, X.、Ma, X.-L.(2013)。C1q/tumor necrosis factor-related protein-9, a novel adipocytederived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation。Circulation，128(11 Suppl. 1)，S113-S120。
36.	Sakuma, K.、Yamaguchi, A.(2012)。Novel intriguing strategies attenuating to sarcopenia。Journal of Aging Research，2012。
37.	Yin, X.、Zheng, Y.、Liu, Q.、Cai, J.、Cai, L.(2012)。Cardiac response to chronic intermittent hypoxia with a transition from adaptation to maladaptation: The role of hydrogen peroxide。Oxidative Medicine and Cellular Longevity，2012。
38.	Williams, A. L.、Chen, L.、Scharf, S. M.(2010)。Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia。Sleep and Breathing，14(1)，51-57。
39.	Timmons, J. A.、Baar, K.、Davidsen, P. K.、Atherton, P. J.(2012)。Is irisin a human exercise gene?。Nature，488，E9-E10。
40.	Thorp, D. B.、Haist, J. V.、Leppard, J.、Milne, K. J.、Karmazyn, M.、Noble, E. G.(2007)。Exercise training improves myocardial tolerance to ischemia in male but not in female rats。American Journal of Physiology: Regulatory, Integrative and Comparative Physiology，293(1)，R363-R371。
41.	Zhou, X.、Li, R.、Liu, X.、Wang, L.、Hui, P.、Chan, L.、Hu, Z.(2016)。ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity。Scientific Reports，6。

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