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題名：山苦瓜攝食和運動訓練對老鼠骨骼肌脂肪代謝基因表現和耐力運動表現之影響
書刊名：體育學報
作者：王宏豪 引用關係／林乃君 引用關係／黃滄海 引用關係／謝伸裕 引用關係
作者(外文)：Wang, Hung-hao／Lin, Nai-chun／Huang, Tsang-hai／Hsieh, Sandy S.
出版日期：2017
卷期：50:3
頁次：頁257-267
主題關鍵詞：山苦瓜；過氧化體增殖劑活化受器；耐力訓練；脂肪氧化；Bitter melon；PPAR；Endurance exercise；Fat oxidation
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緒論：過氧化體增殖劑活化受器(PPAR)受運動訓練的活化可提升脂肪代謝下游基因之表現，而台灣山苦瓜具有活化多項PPARs亞群之能力，而其所提升的脂肪代謝指標皆與運動訓練產生之脂肪代謝效果相似。本研究期望藉由山苦瓜攝食和運動訓練的交互影響，探討其對脂肪代謝的效果是否有加成效果。方法：將47隻SD大鼠依山苦瓜劑量高低和有無運動訓練分成六組：一、控制組(C, n = 9)：一般餵食。二、低劑量組(LBM, n = 8)：5%山苦瓜萃物。三、高劑量組(HBM, n = 8)：8%山苦瓜萃物。四、訓練組(E, n = 9)：耐力運動訓練。五、訓練與低劑量組(ELBM, n = 7)：耐力運動訓練加上5%山苦瓜萃物。六、訓練與高劑量組(EHBM, n = 6)：耐力運動訓練加上8%山苦瓜萃物。六週後進行衰竭運動測試，取其股四頭肌實施半定量反轉錄-聚合酶鏈鎖反應(semi-quantitative RT-PCR)分析脂肪酸代謝相關基因之表現。統計以二因子變異數分析以及杜凱氏事後比較，顯著水準為p ＜ .05。結果：山苦瓜攝食顯著提升脂肪酸氧化作用UCP3和PDK4以及PPAR δ的表現量，但對脂肪儲存基因SCD1和吸收基因CD36等的表現則無影響，運動介入對脂肪代謝相關基因的影響較不一致。結論：山苦瓜攝食顯著增加骨骼肌脂肪酸氧化基因表現，但運動介入並無顯著影響。
Introduction: Recent study has confirmed that high-activation of peroxisome proliferator-activated receptor (PPAR) by exercise training can enhance downstream gene expression and the utilizing of fatty acids (FA). It has been demonstrated that Taiwan bitter melon (BM) possesses ability to activate different types of PPARs, and enhance FA metabolism similar to exercise training. The purpose of this study was to investigate the effects of BM supplementation and exercise training on gene expression involved in fat metabolism and endurance performance. Methods: Forty-seven 8 wk-old Sprague-Dawley rats were divided into 6 groups: 1. Control (C, n = 9); 2. Low BM feeding (LBM, n = 8):5% BM extract supplementation; 3. High BM feeding (HBM, n = 8): 8% BM extract supplementation; 4. Exercise training (E, n = 9); 5. Low BM feeding and exercise (ELBM, n = 7): 5%BM extract supplementation with exercise; 6. High BM feeding and exercise (EHBM, n = 6): 8% BM extract supplementation with exercise. A progressive exercise training protocol was adopted in speed (up to 28 m / min) and duration (up to 50 min) for 6 weeks. Rats were sacrificed after exhaustive exercise at the end of experiment. The semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) was used to detect FA-related downstream gene expression of the quadriceps muscles. Two-way ANOVA and Tukey’s test were used to analyze the differences among groups. The significant level was set at p ＜ .05. Results: BM supplementation significantly raised the expression of UCP3 (uncoupling protein 3), PDK4 (pyruvate dehydrogenase kinase 4) and PPARδ gene. The expressions of SCD1 (steroyl-CoA-desaturase) and CD36 (FA transporter) showed no significant differences among the groups. The effects of exercise training on expression of genes related to FA metabolism were inconsistent. Conclusions: BM, but not exercise training, may increase expression of FA oxidation genes in skeletal muscle.
期刊論文
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5.林嘉志、陸康豪(20090300)。基因轉殖的超級耐力鼠：原理與分子機轉。中華體育季刊，23(1)=88，46-57。new window  延伸查詢new window
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學位論文
1.曾雅旻(2006)。山苦瓜對apoE剔除鼠脂質代謝之影響(碩士論文)。國立臺灣師範大學，臺北市。  延伸查詢new window
2.趙哲毅(2003)。苦瓜活化過氧化體增殖劑活化受器及改變脂質代謝相關基因之表現(博士論文)。國立臺灣大學，臺北市。  延伸查詢new window
3.謝婉郁(2005)。山苦瓜改善血糖血脂代謝異常之效應探討(碩士論文)。國立臺灣大學，臺北市。  延伸查詢new window
 
 
 
 
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