巴金森氏症病人經歷身、心、社會功能性改變，進而產生疲憊與憂鬱症狀。本研究目的為探討巴金森氏症病人之憂鬱症狀及相關因素，以提供臨床醫護人員將憂鬱症狀列為巴金森氏症病人之常規性評估。研究設計為橫斷性相關性研究，以問卷調查法訪問130位研究對象之憂鬱量表、疲憊量表、社會支持及人口學屬性。研究結果顯示婚姻狀況、侯葉分級、共病症數目、社會支持、疲憊可預測憂鬱症狀，解釋28.3%總變異量。病人有配偶者、侯葉分級愈輕、共病症數目愈少、社會支持愈高及疲憊程度愈輕，整體憂鬱症狀得分較低。護理人員需了解巴金森氏症病人在不同的疾病階段經歷的疲憊感，了解其憂鬱症狀及影響因素，鼓勵病人多參與活動，增加社交網絡，減少心中之孤寂感，以降低憂鬱心情。

Patients with Parkinson's disease must face changes in their physical, mental, and social functions. One such critical changes is that in the psychological dimension; psychological changes that can produce fatigue and depression. This study explored depression and its associated factors in patients with Parkinson's disease. In this cross-sectional correlational study, 130 participants were recruited for interview. Four inventories, namely the geriatric depression scale, fatigue inventory, social support, and basic demographic data, were completed. Data were analyzed using independent t tests, analyses of variance, the Pearson product-moment correlation coefficient, and linear multiple regression. The multiple regression analysis results revealed that marital status, Hoehn and Yahr stage, number of comorbidities, social support, and degree of fatigue could explain 28.3% of depression variance and were related to depression severity. Marital status had a significant influence on depression. Patients without spouses had higher depression scores than did married patients. The factors of having a spouse, a lower Hoehn and Yahr stage, fewer comorbidities, more social support, and a lower degree of fatigue were all correlated with a lower degree of depression. Nurses should note that patients with Parkinson's disease may experience depression and subsequent fatigue in different stages of disease progression. The rigorous provision of advice to patients with Parkinson's disease is necessary. Nurses should encourage patients to attend hospital and community activities, improve their social lives, and reduce their loneliness to enable their depression and subsequent fatigue to be reduced to the lowest possible degree.