This paper described the nursing experience for caring a 27year-old female patient with stage three colon cancer while facing the first chemotherapy. The period of care was between the 1st of December in 2015and the 9th of January in 2016. By observation, physical assessment, therapeutic counseling, and other methods, the data were collected. The Gordon 11 item functional health patterns were used for assessment. According physiological, psychological, and social aspects, the patient was identified having experienced anxiety, pain, potential dangerous infections, and other nursing problems. During the period of care, concerns and accompaniment established a favorable therapeutic relationship. The caring team communicated the treatment plan to the patient and provided relevant information to increase her sense of control of the disease. Other patients' sharing of experiences lowered her anxiety and increased her positive thoughts, while regular administration of pain relief and provision of a comfortable posture with pressure point massaging and aromatherapy effectively controlled the discomfort from post-surgical pain. Education on post-op wound care and infection prevention was also provided to the patient. We hope that this sharing of experiences can provide a reference for future practices.