This paper described the experience of nursing a patient who suffered from infective endocarditis related to periodontal treatments after repairmen of the mitral valves and resection of the vegetation. The nursing period was from 5/1/2015 to 6/12/2015. This study implemented the Gordon's 11 function health patterns as an assessment method and collected information by systemic observation, communication, and therapeutic interviews. As a result, infection, risk for activity intolerance, and anxiety were identified as nursing problems of the patient. By applying sympathy, mental supports, and relaxation skills to encourage the patient to express emotion, so the patient can have correct concepts about the disease and positive attitudes toward the illness. The individualized rehabilitation was intervened to assist the patient regain the abilities to daily life and improve the quality of life as the patient returned home. Providing care for patients with infective endocarditis related to dental treatments is a challenged process. Nursing staff should not only focus on the physical needs but also pay attention to psychosocial perspectives of the patients. This nursing experience is expected to share with nurses who care for similar patients in the future.