Targeting Brain-derived Neurotrophic Factor (BDNF) Signaling Pathway as a Treatment Strategy for Depression_

:::

詳目顯示

第 1 筆 / 總合 1 筆

/1頁

來源文獻資料
摘要
外文摘要
引文資料

題名：	Targeting Brain-derived Neurotrophic Factor (BDNF) Signaling Pathway as a Treatment Strategy for Depression
書刊名：	Taiwanese Journal of Psychiatry
作者：	蔡世仁
作者(外文)：	Tsai, Shih-jen
出版日期：	2018
卷期：	32:2
頁次：	頁103-113+a2
主題關鍵詞：	重度憂鬱症；抗憂鬱藥；腦源神經滋養因子；酪氨酸激酶B；Major depressive disorders；Antidepressants；Brain-derived neurotrophic factor；BDNF；Tyrosine kinase B
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:0 點閱:7

抗憂鬱藥通常是作為憂鬱症的第一線治療選擇。然而部分的憂鬱症病人對抗憂鬱藥治療反應不佳，而且抗憂鬱藥的療效通常需使用一段時間才出現，所以憂鬱症的藥物治療對精神科醫師仍然是很大的挑戰。近二十年來的研究為憂鬱症的神經營養假說提供了有力證據，壓力及憂鬱造成海馬的腦源神經滋養因子(BDNF)減少，治療回復這個腦區的腦源神經滋養因子，並且以這個信息路徑生成新的神經細胞。這個機轉可提供一種新的治療憂鬱症的方法，達到更快的療效及治療效果。這一方面的藥物目前在動物的研究已有不錯的抗鬱效果，包括能夠增加腦源神經滋養因子生成的藥物（半胱胺，溴氰菊酯，鋅，硫化氫，鎂，S 47445， TC G-1008，丁酸鈉，肌苷，薑黃素，利魯唑，紫羅蘭鹼），激發腦源神經滋養因子受體的藥物（二異黃酮，異氟醚）和增加腦源神經滋養因子／腦源神經滋養因子前驅物比率的藥劑（阿托伐他汀，齊留通）。這些藥劑需要進一步臨床測試評估其療效及副作用，期望透過憂鬱症的神經營養假說提供抗憂鬱藥物的發展一個嶄新的方向。

以文找文

Major depressive disorder (MDD) is a common mental disorder accounting for significant morbidity and an increase in mortality worldwide. Antidepressants are often recommended as first-line treatment options in MDD patients. But the clinical management of depression with antidepressants remains a major concern for psychiatrists, and there is a need for more effective and quick onset antidepressants beyond the monoaminergic modulation. Studies in recent two decades have provided strong evidence for the neurotrophic hypothesis of MDD, suggesting that stress and antidepressant treatments exert opposing influences on the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. BDNF-mediated changes in adult hippocampal neurogenesis is critical for the therapeutic actions of antidepressant treatments. Therefore, up-regulation of BDNF signaling represents an intriguing opportunity to enhance response rates, and to have faster therapeutic onset in MDD. Those drugs that have received preclinical testing include agents that increase BDNF levels (cysteamine, deltamethrin, zinc, hydrogen sulfide, magnesium, S 47445, TC G-1008, sodium butyrate, inosine, curcumin, riluzole, and harmine), agents that activate BDNF receptors (7,8-dihydroxyflavone, and isoflurane), and agents that increase BDNF/proBDNF ratio (atorvastatin, and zileuton). The neurotrophic hypothesis of MDD may provide opportunity to develop faster and more efficient antidepressant drugs with higher response rates.

以文找文

期刊論文
1.	Tsai, S. J.、Cheng, C. Y.、Yu, Y. W.、Chen, T. J.、Hong, C. J.(2003)。Association study of a brain-derived neurotrophicfactor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response。Am. J. Med. Genet. B. Neuropsychiatr. Genet.，123b，19-22。
2.	Binder, D. K.、Scharfman, H. E.(2004)。Brain-derived neurotrophic factor。Growth Factors，22，123-131。
3.	Duman, R. S.、Heninger, G. R.、Nestler, E. J.(1997)。A molecular and cellular theory of depression。Arch. Gen. Psychiatry，54，597-606。
4.	Hirschfeld, R. M.、Montgomery, S. A.、Aguglia, E.(2002)。Partial response and nonresponse to antidepressant therapy: current approaches and treatment options。J. Clin. Psychiatry，63，826-837。
5.	Smith, M. A.、Makino, S.、Kvetnansky, R.、Post, R. M.(1995)。Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus。The Journal of Neuroscience，15(3)，1768-1777。
6.	Smith, M. A.、Makino, S.、Kvetnansky, R.、Post, R. M.(1995)。Effects of stress on neurotrophic factor expression in the rat brain。Ann. N. Y. Acad. Sci.，771，234-239。
7.	Nibuya, M.、Morinobu, S.、Duman, R. S.(1995)。Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments。J. Neurosci.，15，7539-7547。
8.	Nibuya, M.、Nestler, E. J.、Duman, R. S.(1996)。Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus。J. Neurosci.，16，2365-2372。
9.	Duman, R. S.(2004)。Role of neurotrophic factors in the etiology and treatment of mood disorders。Neuromolecular Med.，5，11-25。
10.	Pandey, G. N.、Ren, X.、Rizavi, H. S.、Conley, R. R.、Roberts, R. C.、Dwivedi, Y.(2008)。Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in postmortem brain of teenage suicide victims。Int. J. Neuropsychopharmacol.，11，1047-1061。
11.	Beyer, J. L.、Krishnan, K. R.(2002)。Volumetric brain imaging findings in mood disorders。Bipolar. Disord.，4，89-104。
12.	Cheng, C. Y.、Hong, C. J.、Yu, Y. W.、Chen, T. J.、Wu, H. C.、Tsai, S. J.(2005)。Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males。Brain Res. Mol. Brain Res.，140，86-90。
13.	Tsai, S. J.(2005)。Is autism caused by early hyperactivity of brain-derived neurotrophic factor?。Med. Hypotheses，65，79-82。
14.	Hong, C. J.、Liou, Y. J.、Tsai, S. J.(2011)。Effects of BDNF polymorphisms on brain function and behavior in health and disease。Brain Res. Bull.，86，287-297。
15.	Chao, M. V.、Bothwell, M.(2002)。Neurotrophins: to cleave or not to cleave。Neuron，33，9-12。
16.	Reichardt, L. F.(2006)。Neurotrophin-regulated signalling pathways。Philos. Trans. R. Soc. Lond. B. Biol. Sci.，361，1545-1564。
17.	Scharfman, H.、Goodman, J.、Macleod, A.、Phani, S.、Antonelli, C.、Croll, S.(2005)。Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats。Exp. Neurol.，192，348-356。
18.	Siuciak, J. A.、Lewis, D. R.、Wiegand, S. J.、Lindsay, R. M.(1997)。Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)。Pharmacol. Biochem. Behav.，56，131-137。
19.	Adachi, M.、Barrot, M.、Autry, A. E.、Theobald, D.、Monteggia, L. M.(2008)。Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy。Biol. Psychiatry，63，642-649。
20.	Schmidt, H. D.、Duman, R. S.(2007)。The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressivelike behavior。Behav. Pharmacol.，18，391-418。
21.	Tsai, S. J.(2017)。Role of neurotrophic factors in attention deficit hyperactivity disorder。Cytokine Growth Factor Rev.，34，35-41。
22.	Nowak, G.、Legutko, B.、Szewczyk, B.、Papp, M.、Sanak, M.、Pilc, A.(2004)。Zinc treatment induces cortical brain-derived neurotrophic factor gene expression。Eur. J. Pharmacol.，492，57-59。
23.	Tsai, S. J.(2006)。Cysteamine-related agents could be potential antidepressants through increasing central BDNF levels。Med. Hypotheses，67，1185-1188。
24.	Shieh, C. H.、Hong, C. J.、Huang, Y. H.、Tsai, S. J.(2008)。Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice。Prog. Neuropsychopharmacol Biol. Psychiatry，32，1590-1594。
25.	Tsai, S. J.(2006)。Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent。Med. Hypotheses，66，605-608。
26.	Takasaki, I.、Oose, K.、Otaki, Y.(2013)。Type II pyrethroid deltamethrin produces antidepressant-like effects in mice。Behav. Brain Res.，257，182-188。
27.	Mlyniec, K.、Starowicz, G.、Gaweł, M.、Frąckiewicz, E.、Nowak, G.(2016)。Potential antidepressant-like properties of the TC G-1008, a GPR39 (zinc receptor) agonist。J. Affect Disord.，201，179-184。
28.	Pochwat, B.、Sowa-Kucma, M.、Kotarska, K.、Misztak, P.、Nowak, G.、Szewczyk, B.(2015)。Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway。Psychopharmacology，232，355-367。
29.	Hu, M.、Zou, W.、Wang, C. Y.(2016)。Hydrogen sulfide protects against chronic unpredictable mild stressinduced oxidative stress in hippocampus by upregulation of BDNF-TrkB pathway。Oxidative Medicine and Cellular Longevity，2016。
30.	Kroczka, B.、Zieba, A.、Dudek, D.、Pilc, A.、Nowak, G.(2000)。Zinc exhibits an antidepressant-like effect in the forced swimming test in mice。Pol. J. Pharmacol.，52，403-406。
31.	Mendez-David, I.、Boursier, C.、Domergue, V.(2017)。S 47445 produces antidepressant- and anxiolytic-like effects through neurogenesis dependent and independent mechanisms。Front. Pharmacol.，8，462。
32.	Han, A.、Sung, Y. B.、Chung, S. Y.、Kwon, M. S.(2014)。Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus。Neuropharmacology，81，292-302。
33.	Hayley, S.、Litteljohn, D.(2013)。Neuroplasticity and the next wave of antidepressant strategies。Front. Cell. Neurosci.，7，218。
34.	Muto, J.、Lee, H.、Lee, H.(2014)。Oral administration of inosine produces antidepressant-like effects in mice。Sci. Rep.，26(4)，4199。
35.	Gourley, S. L.、Espitia, J. W.、Sanacora, G.、Taylor, J. R.(2012)。Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice。Psychopharmacology，219，805-814。
36.	Fortunato, J. J.、Réus, G. Z.、Kirsch, T. R.(2010)。Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus。J. Neural Transm.，117，1131-1137。
37.	Jang, S. W.、Liu, X.、Yepes, M.(2010)。A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyfl avone。Proc. Natl. Acad. Sci. USA，107，2687-2692。
38.	Liu, X.、Liu, X.、Chan, C. B.、Jang, S. W.(2010)。A synthetic 7, 8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect。J. Med. Chem.，53，8274-8286。
39.	Antila, H.、Ryazantseva, M.、Popova, D.(2017)。Isoflurane produces antidepressant effects and induces TrkB signaling in rodents。Sci. Rep.，7，7811。
40.	Chang, H. A.、Wang, Y. H.、Tung, C. S.、Yeh, C. B.、Liu, Y. P.(2016)。7,8-Dihydroxyflavone, a tropomyosin-kinase related receptor B agonist, produces fast-onset antidepressant-like effects in rats exposed to chronic mild stress。Psychiatry Investig.，13，531-540。
41.	Tsai, S. J.(2006)。The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression。Med. Hypotheses，66，319-322。
42.	Lopez, S.、Peiretti, F.、Bonardo, B.、Juhan-Vague, I.、Nalbone, G.(2000)。Effect of atorvastatin and fluvastatin on the expression of plasminogen activator inhibitor type-1 in cultured human endothelial cells。Atherosclerosis，152，359-366。
43.	Zhou, L.、Xiong, J.、Lim, Y.(2013)。Upregulation of blood proBDNF and its receptors in major depression。J. Affect Disord.，150，776-784。
44.	Tsai, S. J.(2017)。Role of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in psychological stress and depression。Oncotarget，8，113258-113268。
45.	Tsai, S. J.(2007)。The P11, tPA/plasminogen system and brainderived neurotrophic factor: implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants。Med. Hypotheses，68，180-183。
46.	Lahlou-Laforet, K.、Alhenc-Gelas, M.、Pornin, M.(2006)。Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease。Am. J. Cardiol.，97，1287-1291。
47.	Tsai, S. J.(2007)。Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression。Med. Hypotheses，68，1296-1299。
48.	Ludka, F. K.、Zomkowski, A. D.、Cunha, M. P.(2013)。Acute atorvastatin treatment exerts antidepressant-like effect in mice via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and increases BDNF levels。Eur. Neuropsychopharmacol.，23，400-412。
49.	Li, D. D.、Xie, H.、Du, Y. F.(2018)。Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice。J. Affect Disord.，227，672-680。
50.	Yang, F. Y.、Lu, W. W.、Lin, W. T.、Chang, C. W.、Huang, S. L.(2015)。Enhancement of neurotrophic factors in astrocyte for neuroprotective effects in brain disorders using lowintensity pulsed ultrasound stimulation。Brain Stimul.，8，465-473。
51.	Tsai, S. J.(2015)。Transcranial focused ultrasound as a possible treatment for major depression。Med. Hypotheses，84，381-383。
52.	Tsai, S. J.(2007)。TrkB partial agonists: potential treatment strategy for major depression。Med. Hypotheses，68，674-676。
53.	Tsai, S. J.、Hong, C. J.、Liou, Y. J.(2010)。Effects of BDNF polymorphisms on antidepressant action。Psychiatry Investig.，7，236-242。
54.	Eisch, A. J.、Bolaños, C. A.、de Wit, J.(2003)。Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression。Biol. Psychiatry，54，994-1005。
55.	Sen, S.、Duman, R.、Sanacora, G.(2008)。Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications。Biol. Psychiatry，64，527-532。
56.	Voegeli, G.、Ramoz, N.、Shekhtman, T.、Courtet, P.、Gorwood, P.、Kelsoe, J. R.(2016)。Neurotrophin genes and antidepressant-worsening suicidal ideation: a prospective case-control study。Int. J. Neuropsychopharmacol.，19(11)，pyw059。
57.	Tsai, S. J.(2005)。Possible involvement of the BDNF-dependent pathway in treatment-emergent suicidality or decreased response to antidepressants。Med. Hypotheses，65，942-946。
58.	Fournier, N. M.、Duman, R. S.(2012)。Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression。Behav. Brain Res.，227，440-449。
59.	Kao, C. F.、Liu, Y. L.、Yu, Y. W.(2018)。Gene-based analysis of genes related to neurotrophic pathway suggests association of BDNF and VEGFA with antidepressant treatment-response in depressed patients。Sci. Rep.，8，6983。
60.	Iga, J.、Ueno, S.、Yamauchi, K.(2007)。Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder。Prog. Neuropsychopharmacol. Biol. Psychiatry，31，658-663。

推文
推薦
引用網址
引用嵌入語法
轉寄

top

:::

相關期刊
相關論文
相關專書
相關著作
熱門點閱

1.	A Gene-gene Interaction between the Vascular Endothelial Growth Factor A and Brain-derived Neurotrophic Factor Genes Is Associated with Psychological Distress in the Taiwanese Population

無相關博士論文

無相關書籍

無相關著作

1.	Mental Health Services in Malaysia
2.	Detoxication Phobia in a Methadone Reduction Program: A Case Report
3.	Acute Liver Injury after Initiating Atomoxetine in a Girl Patient with ADHD, Autism, and Epilepsy: The First Case Report in Taiwan
4.	Catatonia Associated with Nitroglycerin Abuse
5.	The Need of More Interdisciplinary Collaboration in Understanding Negative Symptoms
6.	Quetiapine Shows Cross-reactivity in Urine Drug Screening for Ketamine
7.	Correlations between Glucose-insulin Profiles and Serum Brain-derived Neurotrophic Factor Level in Patients with Major Depressive Disorder before and during Antidepressant Treatment
8.	Effect of Mindfulness Training (Body Scan) on the Five-item Brief Symptom Rating Scale of Depressive Inpatients of Military Personnel: A Pilot Study
9.	Prescription Patterns and Safety Monitoring Practices in Medication for Youths with Attention-deficit/Hyperactivity Disorder
10.	Possession State by an Animal
11.	Cerebellar Arachnoid Cyst-associated Mental Disorder Presented Like Schizophrenia
12.	Risk of Hyponatremia Induced by a Selective Serotonin Reuptake Inhibitor: A Care Report
13.	Differences in Electrocardiographic Findings between Oder Adult Patients with Bipolar Disorder and Schizophrenia
14.	Th17 and Th2 Shift Immune Response in Patients with Chronic Schizophrenia
15.	The Combined Treatment of Foot Bath and Antidepressant Reduces the Depressive Symptoms and Suicidal Ideation

QR Code

臺灣人文及社會科學引文索引資料庫系統

詳目顯示

臺灣人文及社會科學引文索引資料庫