A vaccine against hepatitis C virus (HCV) has yet to be developed. However, the development of treatments for chronic HCV infection has accelerated over the past few years; rapid progress has been made from traditionally prescribed single interferon medication to combined pegylated interferon and ribavirin, and finally to direct-acting antivirals (DAAs). Patients treated with DAAs have exhibited a sustained virologic response rate of 90%; however, oral DAA regimens are expensive and frequently interact with other drugs. Thus, pharmacists require an effective method to avoid dispensing drugs that interfere with one another. In this study, we proposed the use of a smartphone APP and drug counseling hotline for seeking information on drug interactions to replace the Micromedex and effectively shorten search times. We found that patient satisfaction increased from 3.2 ± 0.7 to 4.6 ± 0.4 points (P = 0.04). In addition, pharmacist satisfaction increased from 3.1 ± 0.4 to 4.8 ± 0.2 points (P = 0.02).