According to the characteristics of the decision factors of the library selection locations, such as information incompleteness and their grey correlation, fuzzy, aiming at the disadvantages of the traditional direct of targets sequencing which neglects uncertainties and opposing factors, an optimization of the Library selection locations is established based on the set pairs analysis method. Finally, combining variation coefficient weight with set pairs analysis of the two methods can be more comprehensive to sort the superior and inferior of the library selection, and sort of instance analysis results fulfill with the objective reality.