The intravenous drug dosage error resulting in unstable vital signs in one child was found in our PICU (Pediatric Intensive Care Unit). We analyzed data from the intravenous medication checklist and found that the rate of incorrect intravenous administration was 3.7%. After conducting interviews and summarizing the interview results, we concluded the following causes: the nurses possessed inadequate ability to determine the correct medicine dose; standards for storing leftover medicine were not established; leftover medicines were improperly labeled, doses were not double-checked by another nurse; the time pressure of keeping dosage records leading to mistakes occurring easily; and the nurses diluted drugs and stored leftover medicine according to their experience only. The aim of this project was to decrease incorrect intravenous administration to 0%. Strategies of this project included completing a user guide for common drugs, providing nurse's continuous educational program on intravenously administering drugs, designing stickers for labeling leftover medicine, adding medicine doses on the medicine administration record, establishing computerized order management system for automatically calculating the appropriate medicine dose, and developing double-checking procedure for intravenous administration. After this project, incorrect intravenous administration rate decreased to 0% and no adverse medication event occurred in nearly one and half year. The result indicated the intervention of this project can increase accuracy of intravenous drug infusion and effectively maintain drug safety for child inpatients.