The purposes of the project were to improve the integrity of Sengstaken-Blakemore tube (S-B tube) placement process and care for nurses in intensive care units. Before the improvement program, the rate of integrity of nursing care for S-B tube placement process was 38.3%. The causes were: insufficient knowledge about S-B tube placement process (only 52.1% correctness), incompleteness of material preparation, unfamiliarity with the S-B tube placement, dispersion of the appliance, lack of in-service education and training, lack of revision of standard operating practices, lack of evaluation for coaching new staff. We implemented the following interventions, including developing a guidelines manual, providing a complete S-B package, designing a checklist for S-B tube placement, developing an evaluation form for training new nurses; and developing an in-service education and training program. After the improvement program, the completion rate increased from 38.3% to 91%, the accuracy rate of nurses' knowledge increased from 52.1% to 91%. The program has improved the integrity and timeliness of S-B tube placement and enhanced the quality of care.