This report described the nursing experience of caring a patient with diverticulitis relapse who had aeromonas hydrophila infection, leading to influence on his physiological and mental status. The nursing experience lasted from 6/7/2015 to 6/23/2015. Gordon's eleven types of functional health assessment tool was used to assess the patient's condition through observation, interview, and nursing assessment. The primary nursing problems were infection, acute pain, and anxiety. The author provided individual nursing measures on patient's physiological and mental problems, including fever and pain comfort care, maintenance of airway patency and function, avoidance of relapse by active care and teaching, and alleviation of patient's anxiety. The author suggested that nurses not to overlook a disease like diverticulitis and its serious complications.