This article described the nursing experience of caring a patient with end-stage ovarian cancer. The nursing period was from August 6 to August 22, 2016. We used Gordon's 11 functional health patterns assessment tool to assess patient's major health problems, which included pain, nausea, vomiting, and anticipatory grieving. The author used the concept of hospice care to provide a holistic care, including comfort bed positioning, massage, aromatherapy, and breathing meditation to relieve the symptoms of pain, nausea, and vomiting. The emotional expressions of the patient and family members ere embraced with active caring and open-mindedness. In addition, the hospice team introduced the patient and her family to express their expectations and gratitude to each other, and to accompany the patient to reach her last wish. This may help the patient and her family achieve live and die without regrets. This article provides clinical nursing staff with more information in caring for patients with end-stage ovarian cancer.