This report described the nursing experience of caring a HIV patient who was near death for acute liver failure caused by Hepatitis B infection. Due to jaundice, change in the body's appearance, complicated with infection of HIV, the patient could not receive liver transplantation. He encountered the threat of death which negatively impact his physical and psychological health. The nursing period was from November 8 to 18 in 2015. During this period, health assessment skills in five major dimensions were conducted and therapeutic interviews, physical examinations, observations, and direct care were used to collect data. At this stage, it was confirmed that the patient suffered from three health problems - hemorrhage, body image disturbance, and death anxiety. On the other side, the nursing personnel had established a trustable therapeutic relationship through sincere care, listening, communication, and so on. Other than relieving the patient's physical discomfort in accordance with the doctor's advice, the patient's living quality had improved through the nursing measures. The patient thus improved problems like hemorrhage, and developed self-confidence to accept changes in his physical appearance, so that he could experience the value of life, express gratitude, apology, and farewell to his family, while his body, mind, and soul could obtain satisfaction. In the process of care, the author put spiritual care among the patient and his relatives as the first priority, but ignored that the patient needed to say farewell to his same-sex partner as well. As a result, it is suggested that for such type of patients, within the limited timeframe before the end of life, psychological and spiritual care measures should be arranged according to the individuality, so that love can be expressed even more completely. Lastly, it is expected that by sharing this report, the nursing personnel's sensitivity for the terminal patients' psychological and spiritual need can be raised, and spiritual care can be provided timely, so that the patients can leave the world without regret and peacefully.