Hybrid operating rooms are equipped with advanced video equipment that is suitable for heart surgery, vascular stent surgery, or interventional therapy of complicated operations. Nurses in operation rooms may not be well familiar with using the advanced equipment and sometimes causing unexpected issues during the surgery. The reasons for unfamiliarity included lack of experience and knowledge about using the equipment, lack of standard operational procedure (SOP) as a reference, and lack of appropriate training courses. This project aimed to promoting the ability of nurses using equipment in the hybrid operating room. The strategies included creating one-to-one training courses and skill improvement workshop, creating a SOP with detailed diagrams, creating trouble-shooting cards for reference with detailed maintenance contact information, provide application being used in mobile devices to facilitate self-studying. After the improvement project, the familiarity increased from 62.5% to 100%, and accuracy of using the equipment increased from 43.8% to 95.8%. With the success of this project, we hope to help improve nurses' ability to use new equipment and be comfortable with new technologies.