Aerobic biological treatment system is one of the most effective wastewater treatment processes. Due to oxygen transfer which spend high quantity of energy, is the maior part of operation costs. The dissolved oxygen (DO) is one of the most important control parameters in traditional wastewater treatment system. Since it can't response the real status in wastewater system and indicate the endpoint of reaction. It is also not sensitive enough to regulate the operation condition. Therefore excess energy is consumed in the wastewater treatment system. The basic concept of aerobic biological wastewater treatment system is an oxidation-reduction biological reaction and oxygen is the electron acceptor. The oxidation-reduction-potential (ORP) will change following this reaction. Such status may be indicate some special information that can help us to control wastewater treatment properly. This study disscusses the possibility of applying ORP control system from batch reactions using computer automatic monitoring system in laboratory. The result of this study indicates the concentration of materials in reaction such as COD, DO, have good relationship with ORP, By using ORP to monitor and control biological system is feasible and practical.