The objectives of this study were to investigate the knowledge and attitude of registered nurses in Taipei toward the establishment of nursing institutions, and to analyze the associated factors. A sample of 898 nurses were randomly selected from the nurse registration file of Taipei City Health Bureau using an 1/20 ratio. A self-administered structured questionnaire was sent to each of these nurse. The response rate was 32.3% after two follow-up telephone calls. Major findings of this study are as follows: 1. The average score of the knowledge regarding establishing nursing institutions was 8.7 at a ten point scale. 2. Among the respondents, 94.5% chose financial risk as the most important risk of running a nursing institution, while 96.5% chose capital as the most important consideration of starting a nursing institution. 3. Among those who were willing to start a nursing institution 31.2% of total respondents), three of the most important reasons for that attitude were personal interest 94.5), professional self-esteem (93.4%), and independent practice 87.9%). 4. Regarding types of nursing institution if the respondents were going to start a nursing institution, 51.7% chose post partum nursing institution, 37.2% chose home care institutions, and 11.1% chose nursing homes. 5. Multivariate analyses indicated that those who were under age 24, married, and worried about sources of clients, were less likely to start a nursing institution. In order to facilitate the establishmen of nursing institutions, the health authority should work with education authority to offer courses related to nursing institutions and to enhance the services of career planning. In addition, the health authority should also give seminars and distribute booklets to nurses in practice to explain the know-how's of establishing and managing a nursing institution.