Tsutsugamushi disease is one of the endemic rickettsial infections in the Taiwan area. The number of reported has shown an increasing trend since 1989, and case numbers reached a climax in 1993 (231 reported cases and 58 confirmed cases). The main purpose of this investigation was to illustrate the epidem-iological characteristics of Tsutsugamushi Disease in Taiwan. The endemic areas are mainly mountainous areas and isolated islands, such as Taitung County. Hualien County, Penghu County, Kinmen County and Lienkiang County, The seasonal trend showed the disease pre-dominated in the summer and early autumn. Of the 58 confirmed cases, 70.69% showed skin eschar, 89.66% had lymphadenopathy, and 89.66% presented with fever. After applying two of above three symptoms, 98% of the 58 seroconfirmed cases, presented clinical sypmtoms consistent with Tsutsugamushi disease, and the positive prediction value was estimated as 98.28%. In contrast, only 23 of 60 serological indeterminant cases (39%) met the clinical symptoms.