The purpose of this study was to explore the factors influencing the self-care performance and self-care dependence for the patients with schizophrenia or mood disorder in community. Subjects were chosen by convenience sampling from National Taiwan University Hospital, Taipei City Psychiatric Center and Provincial Tau-Yun Psychiatric Center. One hundred and fifty-one questionnaires were completed. The result revealed: (1) the self-care of schizophrenic patients was worse than that of manic-depressive patients. (2)Self-care performance of personal hygiene by these patients was better than other factors. (3)The degree of dependence on drug alliance was higher than other factors. (4)Factors influencing self-care of schizophrenic patients included patients' age, the symptoms of the disease, degree of concerns regarding their illness, family function and the effect of the coping behavior. (5)Factors influencing self-care of mood disorder patients included the number of hospitalization, the duration of the disease, the negative symptoms degree of concerns regarding their illness, family function and the effect of the coping behavior. (6)The negative symptoms and the effect of coping were significant correlated with self-care of schizophrenic patients. The effect of coping were significant correlated with self-care of mood disorder patients. Public Health.