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題名:補陽還五湯降血脂作用
書刊名:中醫藥雜誌
作者:張惠玲吳介信鍾景光林文川陳光偉林昭庚
作者(外文):Chang, Huei-lingWu, Chieh-hsiChung, Jing-gungLin, Wen-chuanChen, Guang-weiLin, Jaung-geng
出版日期:1998
卷期:9:1
頁次:頁53-60
主題關鍵詞:補陽還五湯高血脂大白鼠總膽固醇三酸甘油脂Pou Yan Fan Wu TanHyperlipidemis ratTriglycerideCholesterol
原始連結:連回原系統網址new window
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     補陽還五湯搜載在清朝醫林改錯,主治中風後半身不遂,口眼歪斜,語言蹇澀, 口角流涎,大便乾燥,小便頻數,遺尿不禁,其藥材為黃耆,桃仁,川芎,歸尾,赤芍,地 龍干,藏紅花,本方用的方劑組成為黃耆 150g, 桃仁 7.5 g,川芎 5.6 g,歸尾 7.5 g, 赤芍 7.5 g,地龍干 7.5g, 藏紅花 1.775g,加水於 100 ℃下煮沸一小時,過濾並收集濾 液,藥渣再依同法處理共二次,合併二次濾液,經減壓濃縮後得粗抽取液,進行藥理實驗, 所得結果如下:(一 ) 補陽還五湯對正常的大白鼠的總膽固醇及三酸甘油脂的作用。每天早 晚二次口服補陽還五湯粗提取液 5 gm/kg 一星期後對正常的大白鼠的總膽固醇及三酸甘油 脂有意義的減少。 (二 ) 誘導高血脂的大白鼠。1. 誘導一星期,三星期,四星期高血脂的 大白鼠,其總膽固醇及三酸甘油脂皆比正常值有意義增高。 2. 誘導一星期,三星期,四星 期高血脂的大白鼠, 再每天早晚二次口服補陽還五湯 5 gm/kg 一星期後,分別測得總膽固 醇及三酸甘油脂皆有意義的減少。 3. 誘導一星期,三星期,四星期高血脂的大白鼠,再每 天早晚二次口服補陽還五湯 5 gm/kg 一星期後,高密度脂蛋白含量沒有影響。 由以上實驗 結果得知,本方補陽還五湯對正常的大白鼠及誘導高血脂的大白鼠皆能有意義的降低其中總 膽固醇及三酸甘油脂的含量而高密度脂蛋白含量則沒受到影響。
     Pou Yan Fan Wu Tan was originally reported in the book Yi Lin Gay Chou in Chin Dynasty. Its principle indications are mainly for stroke-induced paraplegia, twisted eyes and mouth, inability to speak, involuntary salivation, dry feces, polyuria, and dripping urea. All the components including 150 gm of Hwang-Chi, 7.5 gm of Tau-Jen, 5.6 gm of Chwang-Chone, 7.5 gm of Guai-Wei, 7.5 gm of Chi-Shou, 7.5 gm of Di-Long-Gan and 1.775 gm of Cang-Hon-Hwa are extracted via distillation and concen-trated to obtain crude extracts for subsequent pharmacological experiments. The results are as described:A. Administration of 5 gm/kg Pou Yan Fan Wu Tan twice perday can significantly reduce total cholesterol and triglycerideslevels without changing HDL levels in normal rats. B. Induction of hyperlipidemia in rats. 1. Rats with one, three or four weeks of hyperlipidemia induction showed a significant increase in total cholesterol and triglycerides levels as compared to normal rats. 2. Rats with one, three or four weeks of hyperlipidemia induction with subsequent administration of 5 gm/kg Pou Yan Fan Wu Tantwice perday for one week showed a significant decrease in total cholesterol and triglycerides levels as compared to controls. 3. Rats with one, three or four weeks of hyperlipidemia induction with subsequent administration of 5gm/kg Pou Yan Fan Wu Tan twice perday for one week showed no change in HDL level as compared to controls. In summary, our results showed that Pou Yan Fan Wu Tan with our special prescription can effectively reduce total cholesterol and triglycerides levels without altering HDL level in either hyperlipidemia or normal rats.
期刊論文
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2.National Institutes of Health Consensus Conference(1985)。Lowering blood cholesterol to prevent heart disease。JAMA,253(14),2080-2090。  new window
3.Scandinavian Simvastatin Survival Study Group(1994)。Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study。Lancet,344(8934),1383-1389。  new window
4.Ginsberg, H. N.(1990)。Lipoprotein physiology and its relationship to atherogenesis。Endocrinol. Meta. Clin. North. Am.,19(2),211-228。  new window
5.Reihner, E.、Rudling, M.、Stahlberg, D.、Berglund, L.、Ewerth, S.、Bjorkhem, I.、Einarsson, K.、Angelin, B.(1990)。Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol。New Engl J. Med,323(4),224-228。  new window
6.Larsen, L.、Illingworth, D. R.(1994)。Drug treatment of dyslipoproteinemia。Med. Clin. North Am.,78(1),225-245。  new window
7.Shepherd, J.、Packard, C. J.、Grundy, S. M.、Yeshurun, D.、Gotto, A. M.、Taunton, O. D.(1980)。Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man。J. Lipid Res.,21(1),91-99。  new window
8.Kinsell, L. W.、Michaels, G. D.、Partridge, J. W.、Boling, L. A.、Balch, H. E.、Cochrane, G. C.(1953)。Effect upon serum cholesterol and phospholipids of diets containing large amounts of vegetable fat。J. Clin. Nutr.,1(3),231-244。  new window
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11.Glueck, C. J.、Oakes, N.、Speirs, J.、Tracy, T.、Lang, J.(1992)。Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias。Am. J. Cardiol.,70(1),1-9。  new window
12.Metherall, J. E.、Waugh, K.、LI, H.(1996)。Progesterone inhibits cholesterol biosynthesis in cultured cells。J. Bio. Chem.,271(5),2627-2633。  new window
13.Connelly, P. W.、Maguire, G. F.、Vezina, C.、Hegele, R. A.、Kuksis, A.(1994)。Kinetics of very low density lipoproteins by lipoprotein lipase。J. Biol. Chem.,269(32),20554-20560。  new window
14.Hargreaves, A. D.、Longan, R. L.、Thomson, M.、Elton, R. A.、Oliver, M. F.、Riemersma, R. A.(1991)。Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol and coronary heart disease in Scotland。BMJ,303(6804),678-681。  new window
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16.Gordon, T.、Castelli, W. P.、Hjortland, M. C.、Kannel, W. B.、Dawber, T. R.(1977)。High density lipoprotein as a protective factor against coronary heart disease。Am. J. Med.,62(5),707-714。  new window
17.Miller, G. J.、Miller, N. E.(1975)。Plasma high density lipoprotein concentration and development of ischaemic heart disease。Lancet,1(7897),16-19。  new window
18.Berglund, F.、Beltz, W. F.、Elam, R. L.、Witztum, J. L.(1994)。Altered apolipoprotein B metabolism in very low density lipoprotein from lovastatin-treated guinea pigs。J Lipid Res,35(6),956-965。  new window
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圖書
1.王清任(1975)。醫林改錯。台北:集文書局。  延伸查詢new window
圖書論文
1.Denke, M. A.、Grundy, S. M.(1995)。The cholesterol lowering diet。Lowering Cholesterol in High-Risk Individuals and Populations。New York:Marcel Dekker, Inc.。  new window
 
 
 
 
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