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題名：作業場所勞工過敏性反應與異氰酸類特異性體質相關性之探討
書刊名：勞工安全衛生研究季刊
作者：李凡／熊映美／陳佳君／劉雨田／周啟馥
作者(外文)：Lee, Fan／Chiung, Yin-mei／Leu, Yu-tien／Chou, Chi-fu／Chen, Gya-jung
出版日期：1998
卷期：6:3
頁次：頁33-46
主題關鍵詞：異氰酸類；IgE抗體；HLA-DQ1；HLA-B40；Isocyanate；IgE
原始連結：連回原系統網址new window
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  • 被引用次數被引用次數:期刊(3) 博士論文(0) 專書(0) 專書論文(0)
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　　　　　本研究是取樣自6家異氯酸類工廠，共採訪了135位勞工，並進一步探討其有或 無呼吸道、皮膚或眼睛症狀者，與體內異氰酸類專一性IgE抗體之產生，及其與第一型及第 二型人類組織複合物抗原之間的關連住。經比較15位作業場所有關之臨床症狀患者與14位 對照組勞工後發現，第二型人類組織複合物抗原中的HLA-DQ1(Chisquare test，P<0.005)、 以及第一型人類組織複合物抗原中的HLA-B40(Chisquare test，P<0.05)與工作場所有關之 過敏病，包括呼吸道、皮膚或眼睛症狀，有正相關性。至於血清內異氰酸類專一性IgE抗體， 在受測試的135位勞工中，包括與作業場所有關之呼吸道症狀(16人次，11.7%)，皮膚病症 狀(11人次，7.4%)及眼睛症狀者(3人次，2.2%)，全呈陰性反應(<0.35KUA/L)。故本研究結 果顯示，異氰酸類所引起之臨床症狀與患者體內IgE抗體濃度無關。但是第二型人類組織複 合物抗原HLA-DQ1、以及第一型人類組織複合物抗原HLA-B40對於勞工是否會對異氰酸類發 生過敏免疫反應，可能具有非常重要的影響。
　　　　　We have undertaken a case study of the association between HLA allele frequency and specific IgE antibody to isocyanate coupled to immunoCAP (Pharmacia CAP System RAST FEIA) among 135 isocyanate workers. We found a positive association of excess of DQl (Chi-square test, P<0.005), and HLA-B40 (Chi-square test, P<0.05) in the 15 work-related isocyanates sensitized cases when compared with 14 referents. As to the serum IgE level, however, surprisingly, all the 135 workers, both in the control and workplace-related diseased group, including 16 workers with respiratory symptoms, 11 workers with dermatologic symptoms as well as 3 workers with eye symptoms, showed negative specific IgE response to TDI or MDI in the RAST test. These findings suggest TDI, MDI-induced symptoms are non-IgE-dependent mediated features, and both of MHC class II allele DQ1 and MHC class I allele B40 are possible important determinants of the specificity of the immune response to a TDI or MDI antigen.
期刊論文
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5.Saetta, M.、Maestrelli, P.、Stefano, A. D.、Marzo, M. D.、Milani, G. F.、Pivirotto, F.、Mapp, C. E.、Fabbri, L. M.(1992)。Effect of Cessation of Exposure to Toluene Diisocyanate (TDI) on Bronchial Mucosa of Subjects with TDI-Induced Asthma。Am Rev Respir Dis，145，169-174。  new window
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11.Mapp, C. E.、Boniotti, A.、Papi, A.、Chitano, P.、Fabbri, L. M.、Ciaccia, A.(1992)。The Products of the Reaction between Toluene Diisocyanate and Water Contract Guinea Pig Bronchi。Eur J. Pharmacol，228，103-106。  new window
12.Erjefalt, I.、Persson, C. G. A.(1992)。Increased Sensitivity to Toluene Diisocyanate (TDI) in Airways Previously Exposed to Low Doses to TDI。Clin Exp Allergy，22，854-862。  new window
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15.Corrigan, C. J.、Kay, A. B.(1990)。CD4 T-lymphocyte Activation in Acute Severe Asthma。Am Rev Respir Dis，141，970-977。  new window
16.Chrettin, I.、Pene, J.、Briere, F.(1990)。Regulation of Human IgE Synthesis in vitro is Determined by Reciprocal Antagonistic Effects of IL-4 and IFN-γ。Eur J. Immunol，20，243-251。  new window
17.Lee, H. J.、Matsuda, I.、Naito, Y.、Yokota, T.、Arai, N.、Arai, K.(1994)。Signals and Nuclear Factor that Regulate the Expression of Interleukin-4 and Interleukin-4 Genes in Helper T cells。J. Allergy Clin Immunol，94，594-604。  new window
18.Dearman, R. J.、Basketter, D. A.、Kimber, I.(1996)。Characterization of Chemical Allergens as a Function of Divergent Cytokine Secretion Profiles Induced in Mice。Toxicol Appl Pharmacol，138，308-316。  new window
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20.Karol, M. H.、Tollerud, D. H.、Campbell, T.、Fabbri, L.、Maestrelli, Saetta M.(1994)。Predictive Value of Airways Hyperresponsiveness and Circulating IgE for Identifying Types of Responses to Toluene Diisocyanate Inhalation Challenge。Am J. Respir Crit Care Med，149，611-615。  new window
21.Chen-Yeung, M.、Malo, J. L.(1994)。Etiological Agents in Occupational Asthma。Eur Respir J.，7，346-371。  new window
22.Skarping, G.、Dalene, M.、Sevensson, B. G.、Littorin, M.、Akesson, B.、Welinder, H.、Skerfving, S.(1996)。Biomarkers of Exposure, Antibodies and Respiratory Symptoms in Workers Heating Polyurethane Glue。Occup Environ Med，53，180-187。  new window
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26.Li, L.、Sad, S.、Kagi, D.、Mosmann, T. R.(1997)。CD8 Tc1 and Tc2 cells Secrete Distinct Cytokine Patterns in vitro and in vivo but Induce Similar Inflammatory Reactions。J. Immunol，158(9)，4152-4161。  new window
27.Sad, S.、Marcotte, R.、Mosmann, T. R.(1995)。Cytokine-Induced Differentiation of Precursor Mouse CD8+ T Cells into Cytotoxic CD8+ T cells Secreting TH1 and TH2 Cytokines。Immunity，2(3)，271-279。  new window
28.Young, R. P.、Barker, R. D.、Pile, K. D.、Cookson, Wo C. M.、Newman, Taylor A. J.(1993)。The Association of HLA-DR3 with Specific IgE to Inhaled Acid Anhydrides。Am J. Respir Crit Care Med，151，219-221。  new window
29.Jerome, S.(1994)。HLA class II Alleles in Isocyanate-Induced Asthma。Am J. Respir Crit Care Med，149，71-75。  new window
30.Fabbri, L. M.、Mapp, C. E.、Balboni, A.、Baricordi, R.(1995)。HLA class II Molecules and Asthma Induced by Toluene Diisocyanate。Int Arch Allergy Immunol，107，400-401。  new window
31.Balboni, A.、Baricordi, O. R.、Fabbri, L. M.、Gandini, E.、Ciaccia, A.、Mapp, C. E.(1996)。Association between Toluene Diisocyanate-Induced Asthma and DQ1 Markers: a Positive Role for Aspartic Acid at Position 57。Eur Respir J.，9，207-210。  new window
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圖書
1.Tiwari, J.、Terasaki, P.(1985)。HLA and Disease Associations。New York：Springer-Verlag。  new window
圖書論文
1.Holgate, S. T.(1993)。What is Really the Cause of Asthma-Both "Extrinsic and Intrinsic" ?。The Genetics of Asthma。Blackwell Scientific Publication。  new window
 
 
 
 
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