Objective: This study assessed medical students' changes in attitude towards psychiatric illnesses during psychiatric internship. Methods: A total of 60 medical students undergoing psychiatric internship in a teaching hospital were selected for study. The attitudes of the interns towards psychiatric illness before and after their psychiatric internship were assessed using a questionnaire. The questionnaire focused on five major factors thought to be related to attitude toward psychiatric illness: 1) attitude toward psychiatric patients; 2) concept of folk therapy; 3) significance of environmental factors in the development of psychiatric illnesses; 4) acceptability of psychiatric programs in the community and 5) significance of life events in the development of psychiatric illnesses. Results: A significant change of attitude towards psychiatric patients was found after psychiatric internship (t=-2.323, p=0.024). Increased interest in psychiatry play a significant role in the change in attitude (F(2,57)=3,79, p<0.05) and concept of psychosocial factors in the explanatory model of the etiology of psychiatric illness (F(2,57)=3,45, p<0.05). There was a sex difference in opinion regarding the concept of folk therapy in psychiatry. Interest in psychiatry was significantly related to the choice of psychiatry as a career. Conclusion: This study confirmed the effectiveness of psychiatric internship in changing attitudes toward psychiatric illnesses. The details of the internship program are also discussed with suggestions for further modification to improve attitudes towards psychiatric illnesses. (Full Text in Chinese)