In general, museums and profit-making galleries are considered at different ends and significance in terms of collections and exhibitions. In reality, they have overlapping interests and concerns in art and its development. How exploring differences and finding connections* between each other is a relevant issue, which the author much concerns during his 12 years of experiences at museum careers. This article is divided into five parts. At the beginning the author obtains the opinions and views of the galleries to museums and their relationship to the galleries by means of a survey. In the second and the third parts, he discusses the roles and the functions of museums and profit-making galleries, respectively, by the nature of both organizations and through the market-oriented point of views. Fourthly, he analyzes the characteristics of a museum director and an art dealer, and then explores ways in which museums and galleries can work together and create interactions to each other in order to the benefit of the whole art-cultural environment and the general public. Lastly, the author sees museums and profit-making galleries as the intermediaries who play the roles of art input and output in the meantime. Furthermore, from the gallery's position, the gallery also plays the roles of the inspector, the intermediary and the supporter of the museum as well. The author proposes an ideal relationship between museums and profit-making galleries at the end, which are in alliance with each other not collusion with. In other words, museums and galleries can work together and make efforts on introducing international art, developing local art and promoting the quality of the public's life. Under a positive art-cultural environment, museums and profit-making galleries, with the mutual benefit and the win-win policy, can go towards the new era of the museum for the next century.