Chronic illness is a long-term disease. It may impact not only the physical, psychological and social dimensions of patients, but also make the family undergo the life of illness. In this paper, I have taken Orem' s self- care theory as a model and referred to documentation related to the nursing care of a patient with three chronic diseases. I discuss seven specific nursing problems encountered during hospitalization and make comparisons with literature. Through this process, I understand how the chronic diseases impact the patients and family and how important the mental support is. Clearly it is important for us to provide better nursing care for the patients with chronic illness and his family.