"Miao Yu" was one of the most characteristic ladies of the Dream of the Red Chamber. She was unsociable, autistic, and mysophobic in personality, and had a eventful and pitiful outcome. Among" the twelve Jin-Ling ladies", her personality traits made herself the most impressive lady for readers. In this article, we analyzed her special personality traits via modern psychiatry concepts, and tried to explain the etiology of her mental derangement. We found that she had the characters of obsessive-compulsive personality disorder, and it could be attributed to her constantly ill childhood and unsteady family. The authors made very precise and vivid description of the characteristic behavior of the victims of this mental illness in the Chinese society hundreds years ago. Most of them could be found in modern psychiatric clinic and that is one of the most valuable contributions he gave us.