The main purpose of this study was to explore the application effects of a self-designed curriculum for developmentally delayed preschoolers. The subjects included 26 experts and teachers in the first draft curriculum evaluation interview, 50 age three to five developmentally delayed preschoolers during the experimental teaching session, and 11 teachers participated in the experimental for the final curriculum evaluation interview. Data were gathered by both the pre-experimental curriculum evaluation form and post-experimental curriculum evaluation form. Data were analyzed by both quantitative and qualitative methods. The main findings were: (1) For the opinions of the curriculum for developmentally delayed preschoolers, most of the experts and teachers showed positive attitudes towards the first draft curriculum for developmentally delayed preschoolers. (2) over 40% of the interviewees presently used Functional curriculum outlines for the Moderately and Severely Mentally Retarded Hong Kong Heep Hong Society for Handicapped Children Developmental Learning Package and Portage Early Education Program as their early intervention curricula. (3) all participating in the experiment teachers gave positive support and high recommendation of the curriculum. (4) both pre-experimental and post-experimental interviewees thought curriculum content broadly connected with daily life and very suitable for developmentally delayed preschoolers. Based on the above findings, some suggestions were made for curriculum content, and future research.