"Melancholia" has been a concept in pre-modern medical philosophy. With the development of modern science, the concept has gradually declined and has been finally replaced by "depression." After Freud’s Mourning and Melancholia, the concept has regained psychoanalytical and philosophical concern, and has been discussed multi-dimensionally in Butler’s socio-political critique. From a psychoanalytical and socio-political concept to a cultural mentality resisting the influence of modernity, this article attempts to explore the renaissance, the development and the loss of the concept of melancholia.