Currently, city clusters have become major spatial entities of regional economic development and urbanization in China. With rapid population and capital flow, regional crossboundary coordination of city clusters becomes a practical issue for the establishment of regional governance system. Cross-boundary conflicts in transportation, ecological environment, and infrastructure resulted from administrative division are becoming more serious, obstructing the overall regional development. Thus, it is imperative to explore an effective regional coordination path. Taking several cross-boundary coordination plans of Jiangsu Province as empirical cases, this paper firstly summarizes the theoretical research and practice on regional governance, and then proposes that cross-boundary coordination plan, as a new path of government-led regional governance, can provide a multi-agent negotiation platform and a spatial planning cooperation platform by transferring the planning into several projects, thus further promoting the coordination of cross-boundary projects and the integrated development of the region.