As one of the poorest countries on the earth, Tanzania anchors its hope on entrepreneurial talents cultivated by university entrepreneurship education to stimulate its economic development and reduce unemployment rate. Following the national guide, the universities have taken measures to implement entrepreneurship education, such as transforming its education targets or missions, constructing cross-disciplinary entrepreneurship curricular systems and founding entrepreneurship development institute. However, due to lack of supportive entrepreneurship environment, lack of participation from different units at the university level, lack of entrepreneurship faculties in the practical process, the development is stuck and unsatisfactory. From the experience of implementing entrepreneurship education, we found that assistant service system consist of comprehensive laws, finance, human resources, market and the like is the base of startups; the government should decontrol the process supervision while the university delivering entrepreneurship education; the universities should break discipline boundaries and form the collaborative model of cross-disciplinary entrepreneurship education instruction.