Peripheral intravenous catheter placement is crucial to the treatment of emergency patients. The common complication is peripheral phlebitis, which not only prolongs the hospital stay and increases the medical burden, but also patient death from sepsis in the severe cases, and resulting medical disputes. Therefore, it is essential that emergency department develop the concept of “infection control” and effective preventive measures to ensure patient safety, improve the cure rate, as well as cut down the medical cost.In 2016, the incidence of peripheral phlebitis in emergency patients in our hospital was 0.02%, therefore, an ad hoc group was set up on February 5th, 2017.The risk factors unveiled include inadequate hand hygiene, no standards for nursing care of peripheral venous catheter, lack of education and training, and inappropriate disinfectants such as lacking of effectiveness and rapid evaporation properties. our implementation measures are: 1. Strengthen the compliance and accuracy of hand washing through “how-to hand hygiene video”, 2. Set up a “standard operation procedure for nursing care of peripheral intravenous catheter placement for emergency patients”, 3. Train the “Mystic Surveyor” team to perform regular surveillance, 4. Hang up “warning signs” and strengthen inspections for patients using “antibiotics, high-concentration and highpermeability drugs, and infusion”, 5. Objective structured clinical examination, 6. Education and training, 7. Use disinfectant with 2% chlorhexidine, etc. The incidence of peripheral phlebitis in emergency patients decreased from 0.02% to 0%. Therefore, the implementation of "infection control" is indeed indispensable to patient safety. Through the sharing of various implementation measures in this ad hoc program, it is expected to contribute to the nursing profession via upgrade quality of care.