This paper mainly explores the economic,social,and cultural significance of reification based on two works: Capital by Karl Marx and History and Class Consciousness by Georg Lukács. Reification is,above all,an economic fact which is inevitable in the systematic operation of modern economy. It characterizes how immediate substantiality is replaced by abstract substantiality, and how the complexification and the rationalization of the latter fragmentizes the entity into a characteristic of a rigid and inertia-prone system.Moreover,it refers to the domination of objectification and substantiality that deprives the self of liberty,sublimity,and autonomy. It is crucial to reexamine the meaning of reification through a holistic approach that combines economic,social,and cultural thought,and to follow the path of Marx via the elucidation of Lukács,especially when the current advocacy of a relatively one-dimensional cultural philosophy suggests a dangerous position that might lead to one-sidedness and distortion.