Centered on the Urban System Planning of Jiangsu Province(2001-2020) and its follow-up work, this paper reviews the historical background, opportunities and challenges, coping strategies, and implementation effects of Jiangsu’s regional planning practice at the end of the 20thcentury. Taking this as reference, the paper discusses the principles that should be paid attention to in the development of regional planning in China. The paper holds that the planning work should closely follow the socio-economic development requirements, focus on the interests of the people, combine market orientation with policy orientation, and make adjustment and improvement in a timely manner. Regional planning is more important in the transitional period of development and should play a better role of macro-economic control. Regional planning is an important tool for the Party and the government to govern the country, so it is necessary to strengthen its attribute as a public policy, grasp major issues, and make strategic decisions. Regional planning involves a wide range of issues and has rich connotations and complex relationships, so importance should be attached to adopting scientific measures and strengthening scientific decisionmaking.